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- W2020846586 abstract "A number of studies have suggested that resistance of target cells to natural killing (NK) may be correlated with their level of expression of major histocompatibility complex (MHC) class I antigens. To examine this hypothesis directly, a NK-sensitive class I-deficient human B-cell line was transfected with MHC class I genes. The expression of transfected HLA, but not H-2, class I gene products resulted in loss of susceptibility to human NK-mediated conjugation and cytolysis. Furthermore, this protection did not extend to cytotoxicity mediated by interleukin 2-stimulated human NK effector cells." @default.
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- W2020846586 date "1989-04-01" @default.
- W2020846586 modified "2023-09-24" @default.
- W2020846586 title "Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes." @default.
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- W2020846586 doi "https://doi.org/10.1073/pnas.86.7.2361" @default.
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