FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020846883> ?p ?o ?g. }

• W2020846883 abstract "Purpose Due to the relative low age of HIV-infected patients, Framingham risk score (FRS) usually estimates a low CVD risk. Lifetime risk estimations use the risk of developing CVD over the course of an individual's remaining lifetime and may be useful in communicating the risk of CVD to young patients. Our aim is to estimate the lifetime risk of CVD in a representative sample of HIV patients under antiretroviral therapy in Spain. Methods Cross-sectional analysis in 10 HIV units across Spain, including information on demographics, HIV disease status, treatment history and cardiovascular risk factors of subject under ART. Lifetime CVD risk was calculated with the method of Berry et al, which classifies the lifetime risk in five mutually exclusive categories: 1. All risk factors are optimal; 2. At least one risk factor is not optimal; 3. At least one risk factor is elevated; 4. One major risk factor is present; and 5. Two or more major risk factors are present. Risk factors included are cholesterol level, blood pressure, diabetes and tobacco smoking. We grouped these five categories in two major groups, low-risk (groups 1+2+3) and high-risk category (groups 4+5). We calculated the prevalence of having a high lifetime risk, and its crude and aOR (adjusted by age, sex, place of origin, education level, transmission category, time since HIV diagnosis, CDC stage, current and nadir CD4 count, HCV coinfection, time on current and total ART, being on the first ART regimen, and PI vs. NNRTI regimen). Results We included 839 subjects free of previous CVD disease: 72% men, median age 45.6y, median CD4 count 598 cells, median time since HIV diagnosis 11y, median time on ART 6.3y, 87% had undetectable VL. Estimated 10-year CVD risk was low (<5%) in 78% of the patients, and intermediate (5–10%) in 20%. Lifetime risk estimation shows a high risk profile for 71.4% of the population studied (≥1 major risk factors). Factors significantly and independently associated with an increased lifetime risk were older age, non-Spanish origin and longer time on ART. Adjusted OR for patients on ART longer than 10 years (vs<5 years) was 2.2 [95% CI 1.13–4.34]. No relationship was found with current or nadir CD4 lymphocyte counts, CDC stage C, HCV confection or type of ART. Conclusions There are significant disparities between the low 10y CVD risk estimated with FRS and the elevated lifetime risk in HIV patients on ART. Prolonged ART is associated with an increased CVD lifetime risk." @default.
• W2020846883 created "2016-06-24" @default.
• W2020846883 creator A5005269604 @default.
• W2020846883 creator A5015434274 @default.
• W2020846883 creator A5019348706 @default.
• W2020846883 creator A5025610151 @default.
• W2020846883 creator A5041223946 @default.
• W2020846883 creator A5052565942 @default.
• W2020846883 creator A5057857416 @default.
• W2020846883 creator A5064606672 @default.
• W2020846883 creator A5072944678 @default.
• W2020846883 creator A5078695847 @default.
• W2020846883 creator A5081385040 @default.
• W2020846883 date "2012-11-11" @default.
• W2020846883 modified "2023-10-18" @default.
• W2020846883 title "High lifetime risk of cardiovascular disease vs low 10-year Framingham risk score in HIV-infected subjects under ART in Spain: the Coronator study" @default.
• W2020846883 cites W2119984740 @default.
• W2020846883 doi "https://doi.org/10.7448/ias.15.6.18109" @default.
• W2020846883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3512548" @default.
• W2020846883 hasPublicationYear "2012" @default.
• W2020846883 type Work @default.
• W2020846883 sameAs 2020846883 @default.
• W2020846883 citedByCount "0" @default.
• W2020846883 crossrefType "journal-article" @default.
• W2020846883 hasAuthorship W2020846883A5005269604 @default.
• W2020846883 hasAuthorship W2020846883A5015434274 @default.
• W2020846883 hasAuthorship W2020846883A5019348706 @default.
• W2020846883 hasAuthorship W2020846883A5025610151 @default.
• W2020846883 hasAuthorship W2020846883A5041223946 @default.
• W2020846883 hasAuthorship W2020846883A5052565942 @default.
• W2020846883 hasAuthorship W2020846883A5057857416 @default.
• W2020846883 hasAuthorship W2020846883A5064606672 @default.
• W2020846883 hasAuthorship W2020846883A5072944678 @default.
• W2020846883 hasAuthorship W2020846883A5078695847 @default.
• W2020846883 hasAuthorship W2020846883A5081385040 @default.
• W2020846883 hasBestOaLocation W20208468832 @default.
• W2020846883 hasConcept C11783203 @default.
• W2020846883 hasConcept C126322002 @default.
• W2020846883 hasConcept C134018914 @default.
• W2020846883 hasConcept C2779134260 @default.
• W2020846883 hasConcept C2781413609 @default.
• W2020846883 hasConcept C50440223 @default.
• W2020846883 hasConcept C555293320 @default.
• W2020846883 hasConcept C71924100 @default.
• W2020846883 hasConceptScore W2020846883C11783203 @default.
• W2020846883 hasConceptScore W2020846883C126322002 @default.
• W2020846883 hasConceptScore W2020846883C134018914 @default.
• W2020846883 hasConceptScore W2020846883C2779134260 @default.
• W2020846883 hasConceptScore W2020846883C2781413609 @default.
• W2020846883 hasConceptScore W2020846883C50440223 @default.
• W2020846883 hasConceptScore W2020846883C555293320 @default.
• W2020846883 hasConceptScore W2020846883C71924100 @default.
• W2020846883 hasIssue "6(Suppl 4)" @default.
• W2020846883 hasLocation W20208468831 @default.
• W2020846883 hasLocation W20208468832 @default.
• W2020846883 hasOpenAccess W2020846883 @default.
• W2020846883 hasPrimaryLocation W20208468831 @default.
• W2020846883 hasRelatedWork W1969463779 @default.
• W2020846883 hasRelatedWork W2070850641 @default.
• W2020846883 hasRelatedWork W2092069233 @default.
• W2020846883 hasRelatedWork W2118587543 @default.
• W2020846883 hasRelatedWork W2188323664 @default.
• W2020846883 hasRelatedWork W2383009242 @default.
• W2020846883 hasRelatedWork W2574508614 @default.
• W2020846883 hasRelatedWork W2900038149 @default.
• W2020846883 hasRelatedWork W2993650375 @default.
• W2020846883 hasRelatedWork W4229452857 @default.
• W2020846883 hasVolume "15" @default.
• W2020846883 isParatext "false" @default.
• W2020846883 isRetracted "false" @default.
• W2020846883 magId "2020846883" @default.
• W2020846883 workType "article" @default.