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- W2020847825 abstract "Allosensitization in cardiac transplant recipients is a growing problem due to the increasing use of left ventricular assist devices and the number of patients undergoing retransplantation. We investigated the effect of two clinically-relevant immunosuppressive regimens on prevention of allosensitization in a rat model of cardiac transplantation. Lewis rats (n=6 per group) were sensitized with Brown-Norway rat skin grafts 7 days before receiving a heterotopic heart transplant (Tx). Following skin grafting, rats received cyclophosphamide (CTX, 15mg/kg/day, orally), mycophenolate mofetil (MMF, 30mg/kg/day, orally), or saline until cardiac transplantation. Following transplantation, immunosuppression consisted solely of oral Cyclosporine A (CsA, 15mg/kg/day) or saline. Antibody levels were determined by complement-mediated cytotoxicity in recipients on the day of skin graft, day of transplantation, and at 1 and 2 weeks after transplantation. Treatment with either CTX or MMF significantly reduced serum antibody titers at 7 days following sensitization, from 1:1600 in saline treated rats to 1:50 and 1:100, respectively, p<0.001. Post-transplant, antibody levels remained low in CTX or MMF-treated rats. Allografts in unsensitized rats treated with saline survived for 7-8 days, whereas allografts in sensitized rats treated with saline were rejected within 24 hours by cellular infiltration. In contrast, treatment of sensitized rats with either CTX or MMF significantly increased allograft survival, each group demonstrating graft survival for >100 days, p<0.001. The data indicate that regimens containing either CTX or MMF reduce B cell activation and allosensitization, and suggest that prospective studies are warranted to compare the relative efficacy of both in sensitized patients awaiting cardiac transplantation." @default.
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- W2020847825 date "2001-02-01" @default.
- W2020847825 modified "2023-09-27" @default.
- W2020847825 title "Prevention of accelerated rejection and prolonged survival in sensitized rats with cyclophosphamide therapy" @default.
- W2020847825 doi "https://doi.org/10.1016/s1053-2498(00)00522-2" @default.
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