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• W2020850832 abstract "Final crossmatch testing is routinely used to assess the risk of antibody‐mediated graft injury/rejection post‐transplant. Analogously, we postulated that quantitative measurements of anti‐donor effector/memory T cells pre‐transplant would independently assess post‐transplant risk. To address this hypothesis, we determined the frequencies of pre‐transplant, donor‐specific interferon‐γ (IFN‐γ) enzyme‐linked immunosorbent spots (ELISPOTs) and correlated the results with post‐transplant outcomes in 37 African American recipients of deceased donor kidney transplants treated with tacrolimus‐ and sirolimus‐based immunosuppression. A positive ELISPOT test (>25 spots/300 000 cells) was detected in 14 (38%) of 37 patients. The incidence of biopsy‐proven acute rejection was 50% (7/14) in ELISPOT‐positive versus 17% (4/23) in ELISPOT‐negative patients (p = 0.036). Calculated glomerular filtration rate (MDRD) at 12 months was 37 ± 16 mL/min in ELISPOT‐positive versus 55 ± 20 mL/min in ELISPOT‐negative patients (p = 0.01). ELISPOT status remained a correlate of allograft function at 12 months by linear regression analysis (p = 0.001), independent of rejection and other contributing variables. Pre‐transplant donor‐directed IFN‐γ ELISPOT assessment of anti‐donor cellular immunity may function as a ‘cellular crossmatch’ and independently correlates with renal allograft function in African Americans receiving tacrolimus‐ and sirolimus‐based immunosuppression." @default.
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• W2020850832 date "2005-08-01" @default.
• W2020850832 modified "2023-09-25" @default.
• W2020850832 title "Pre‐Transplant IFN‐γ ELISPOTs Are Associated with Post‐Transplant Renal Function in African American Renal Transplant Recipients" @default.
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• W2020850832 doi "https://doi.org/10.1111/j.1600-6143.2005.00958.x" @default.
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