Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020860200> ?p ?o ?g. }
- W2020860200 endingPage "1026" @default.
- W2020860200 startingPage "1011" @default.
- W2020860200 abstract "Sphingosine-1-phosphate (S1P) influences various fundamental biological processes by interacting with a family of five G protein-coupled receptors (S1P1-5). FTY720, a sphingosine analogue, which was approved for treatment of relapsing forms of multiple sclerosis, is phosphorylated in vivo and acts as an agonist of four of the five S1P receptor subtypes. Starting from these lead structures we developed new agonists for the S1P1 receptor. The biological activity was tested in vivo and promising ligands were fluorinated at different positions to identify candidates for positron emission tomography (PET) imaging after [(18)F]-labelling. The radioligands shall enable the imaging of S1P1 receptor expression in vivo and thus may serve as novel imaging markers of S1P-related diseases." @default.
- W2020860200 created "2016-06-24" @default.
- W2020860200 creator A5028580335 @default.
- W2020860200 creator A5032034312 @default.
- W2020860200 creator A5037351282 @default.
- W2020860200 creator A5039788950 @default.
- W2020860200 creator A5041513588 @default.
- W2020860200 creator A5087788813 @default.
- W2020860200 date "2015-03-01" @default.
- W2020860200 modified "2023-10-06" @default.
- W2020860200 title "Synthesis of new ligands for targeting the S1P1 receptor" @default.
- W2020860200 cites W1972606659 @default.
- W2020860200 cites W1974678115 @default.
- W2020860200 cites W1977374870 @default.
- W2020860200 cites W1983401069 @default.
- W2020860200 cites W1984423992 @default.
- W2020860200 cites W1988628214 @default.
- W2020860200 cites W1990803922 @default.
- W2020860200 cites W1993930518 @default.
- W2020860200 cites W2002301651 @default.
- W2020860200 cites W2007752718 @default.
- W2020860200 cites W2015554128 @default.
- W2020860200 cites W2021294429 @default.
- W2020860200 cites W2022770236 @default.
- W2020860200 cites W2029343568 @default.
- W2020860200 cites W2029921918 @default.
- W2020860200 cites W2033043158 @default.
- W2020860200 cites W2034896348 @default.
- W2020860200 cites W2035037463 @default.
- W2020860200 cites W2047214839 @default.
- W2020860200 cites W2052757938 @default.
- W2020860200 cites W2053373339 @default.
- W2020860200 cites W2061957367 @default.
- W2020860200 cites W2078502801 @default.
- W2020860200 cites W2080046003 @default.
- W2020860200 cites W2083256058 @default.
- W2020860200 cites W2091237203 @default.
- W2020860200 cites W2093214723 @default.
- W2020860200 cites W2094456671 @default.
- W2020860200 cites W2108598678 @default.
- W2020860200 cites W2117003397 @default.
- W2020860200 cites W2144869962 @default.
- W2020860200 cites W2145586360 @default.
- W2020860200 cites W2169259022 @default.
- W2020860200 cites W2313909300 @default.
- W2020860200 cites W2950042481 @default.
- W2020860200 cites W2950157155 @default.
- W2020860200 cites W2952272289 @default.
- W2020860200 cites W4251094230 @default.
- W2020860200 cites W4362204496 @default.
- W2020860200 doi "https://doi.org/10.1016/j.bmc.2015.01.014" @default.
- W2020860200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25656338" @default.
- W2020860200 hasPublicationYear "2015" @default.
- W2020860200 type Work @default.
- W2020860200 sameAs 2020860200 @default.
- W2020860200 citedByCount "15" @default.
- W2020860200 countsByYear W20208602002015 @default.
- W2020860200 countsByYear W20208602002016 @default.
- W2020860200 countsByYear W20208602002018 @default.
- W2020860200 countsByYear W20208602002019 @default.
- W2020860200 countsByYear W20208602002020 @default.
- W2020860200 countsByYear W20208602002021 @default.
- W2020860200 countsByYear W20208602002022 @default.
- W2020860200 countsByYear W20208602002023 @default.
- W2020860200 crossrefType "journal-article" @default.
- W2020860200 hasAuthorship W2020860200A5028580335 @default.
- W2020860200 hasAuthorship W2020860200A5032034312 @default.
- W2020860200 hasAuthorship W2020860200A5037351282 @default.
- W2020860200 hasAuthorship W2020860200A5039788950 @default.
- W2020860200 hasAuthorship W2020860200A5041513588 @default.
- W2020860200 hasAuthorship W2020860200A5087788813 @default.
- W2020860200 hasConcept C12554922 @default.
- W2020860200 hasConcept C135285700 @default.
- W2020860200 hasConcept C169760540 @default.
- W2020860200 hasConcept C170493617 @default.
- W2020860200 hasConcept C185592680 @default.
- W2020860200 hasConcept C207001950 @default.
- W2020860200 hasConcept C2775842073 @default.
- W2020860200 hasConcept C2776549689 @default.
- W2020860200 hasConcept C2776596873 @default.
- W2020860200 hasConcept C2778703144 @default.
- W2020860200 hasConcept C2778938600 @default.
- W2020860200 hasConcept C29331040 @default.
- W2020860200 hasConcept C54355233 @default.
- W2020860200 hasConcept C55493867 @default.
- W2020860200 hasConcept C86803240 @default.
- W2020860200 hasConcept C95444343 @default.
- W2020860200 hasConcept C98274493 @default.
- W2020860200 hasConceptScore W2020860200C12554922 @default.
- W2020860200 hasConceptScore W2020860200C135285700 @default.
- W2020860200 hasConceptScore W2020860200C169760540 @default.
- W2020860200 hasConceptScore W2020860200C170493617 @default.
- W2020860200 hasConceptScore W2020860200C185592680 @default.
- W2020860200 hasConceptScore W2020860200C207001950 @default.
- W2020860200 hasConceptScore W2020860200C2775842073 @default.
- W2020860200 hasConceptScore W2020860200C2776549689 @default.
- W2020860200 hasConceptScore W2020860200C2776596873 @default.
- W2020860200 hasConceptScore W2020860200C2778703144 @default.