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- W2020867326 abstract "Summary: We studied the effects of clonidine (10 μg/kg i.v.) on the positive feedback between poststenotic myocardial ischemia and cardiac sympathetic nerve activation and on the initiation of poststenotic myocardial ischemia during bilateral carotid occlusion in 12 anesthetized, open-chest dogs. During 20 min of acute severe coronary stenosis, cardiac sympathetic nerve activity increased by 24 ± 6%, poststenotic coronary resistance increased from 0.45 ± 0.05 to 0.61 ± 0.08 mm Hg⋅min⋅100 g/ml, and the poststenotic myocardial lactate consumption of 25 ± 6 μmol/min⋅100 g at 1 min of stenosis was reversed to a net lactate production of 8 ± 3 μmol/min⋅100 g after 20 min of stenosis. An additional 60-s bilateral carotid occlusion increased cardiac sympathetic nerve activity furthermore to 157 ± 7% of control, increased poststenotic coronary resistance to 0.84 ± 0.14 mm Hg⋅min⋅100 g/ml, and increased the net lactate production to 22 ± 6 μmol/min⋅100 g. With heart rate and left ventricular pressure kept constant, clonidine decreased cardiac sympathetic nerve activity to 21 ± 6% of control and prevented any further sympathetic activation during 20 min of coronary stenosis and bilateral carotid occlusion. Conversely, poststenotic coronary resistance and myocardial lactate consumption remained unchanged. Intracoronary clonidine (100 μg) in five of the 12 dogs increased poststenotic coronary resistance from 0.47 ± 0.04 to 0.61 ± 0.05 mm Hg⋅min⋅100 g/ml and reversed the myocardial lactate consumption of 36 ± 4 μmol/min⋅100 g to a net lactate production of 7 ± 5 μmol/min⋅100 g. Our results suggest that clonidine can, by a central nervous action, prevent the sympathetic initiation and aggravation of poststenotic myocardial ischemia and may thus be effective in the treatment of exertional angina." @default.
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- W2020867326 date "1985-11-01" @default.
- W2020867326 modified "2023-09-25" @default.
- W2020867326 title "Clonidine Prevents the Sympathetic Initiation and Aggravation of Poststenotic Myocardial Ischemia" @default.
- W2020867326 doi "https://doi.org/10.1097/00005344-198511000-00026" @default.
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