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- W2020867609 abstract "A novel approach has been demonstrated to construct biocompatible, macroporous 3-D tissue engineering scaffolds containing a continuous macroscopic gradient in composition that yields a stiffness gradient along the axis of the scaffold. Polymeric microspheres, made of poly(D,L-lactic-co-glycolic acid) (PLGA), and composite microspheres encapsulating a higher stiffness nano-phase material (PLGA encapsulating CaCO3 or TiO2 nanoparticles) were used for the construction of microsphere-based scaffolds. Using controlled infusion of polymeric and composite microspheres, gradient scaffolds displaying an anisotropic macroscopic distribution of CaCO3/TiO2 were fabricated via an ethanol sintering technique. The controllable mechanical characteristics and biocompatible nature of these scaffolds warrants further investigation for interfacial tissue engineering applications. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010" @default.
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- W2020867609 date "2010-01-01" @default.
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- W2020867609 title "Three-dimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissues" @default.
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- W2020867609 doi "https://doi.org/10.1002/jbm.a.32765" @default.
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