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• W2020868068 abstract "Genetic makeup of an individual is a strong determinant of the morphologic and mechanical properties of bone. Here, in an effort to identify quantitative trait loci (QTLs) for changes in the simulated mechanical parameters of trabecular bone during altered mechanical demand, we subjected 352 second generation female adult (16 weeks old) BALBxC3H mice to 3 weeks of hindlimb unloading followed by 3 weeks of reambulation. Longitudinal in vivo microcomputed tomography (μCT) scans tracked trabecular changes in the distal femur. Tomographies were directly translated into finite element (FE) models and subjected to a uniaxial compression test. Apparent trabecular stiffness and components of the Von Mises (VM) stress distributions were computed for the distal metaphysis and associated with QTLs. At baseline, five QTLs explained 20% of the variation in trabecular peak stresses across the mouse population. During unloading, three QTLs accounted for 14% of the variability in peak stresses. During reambulation, one QTL accounted for 5% of the variability in peak stresses. QTLs were also identified for mechanically induced changes in stiffness, median stress values and skewness of stress distributions. There was little overlap between QTLs identified for baseline and QTLs for longitudinal changes in mechanical properties, suggesting that distinct genes may be responsible for the mechanical response of trabecular bone. Unloading related QTLs were also different from reambulation related QTLs. Further, QTLs identified here for mechanical properties differed from previously identified QTLs for trabecular morphology, perhaps revealing novel gene targets for reducing fracture risk in individuals exposed to unloading and for maximizing the recovery of trabecular bone's mechanical properties during reambulation." @default.
• W2020868068 created "2016-06-24" @default.
• W2020868068 creator A5012957590 @default.
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• W2020868068 date "2014-07-01" @default.
• W2020868068 modified "2023-10-16" @default.
• W2020868068 title "Quantitative trait loci that modulate trabecular bone's risk of failure during unloading and reloading" @default.
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• W2020868068 cites W1968223455 @default.
• W2020868068 cites W1972766017 @default.
• W2020868068 cites W1973933542 @default.
• W2020868068 cites W1976741643 @default.
• W2020868068 cites W1979968943 @default.
• W2020868068 cites W1984721835 @default.
• W2020868068 cites W1985012226 @default.
• W2020868068 cites W1986131567 @default.
• W2020868068 cites W1992133790 @default.
• W2020868068 cites W1992587657 @default.
• W2020868068 cites W1997899363 @default.
• W2020868068 cites W2003035047 @default.
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• W2020868068 cites W2011622779 @default.
• W2020868068 cites W2012952058 @default.
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• W2020868068 cites W2016256338 @default.
• W2020868068 cites W2017472612 @default.
• W2020868068 cites W2017966093 @default.
• W2020868068 cites W2020695850 @default.
• W2020868068 cites W2030913739 @default.
• W2020868068 cites W2031393561 @default.
• W2020868068 cites W2034650092 @default.
• W2020868068 cites W2035671623 @default.
• W2020868068 cites W2044189631 @default.
• W2020868068 cites W2048481961 @default.
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• W2020868068 cites W2064346787 @default.
• W2020868068 cites W2066749771 @default.
• W2020868068 cites W2072543840 @default.
• W2020868068 cites W2077974816 @default.
• W2020868068 cites W2088181581 @default.
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• W2020868068 doi "https://doi.org/10.1016/j.bone.2014.03.042" @default.
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