FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020870274> ?p ?o ?g. }

• W2020870274 endingPage "18" @default.
• W2020870274 startingPage "13" @default.
• W2020870274 abstract "Neuropathic pain is a long-lasting clinical problem that is often refractory to medical management. Gene transfer of specific genes for therapeutic benefit offers a novel approach to the treatment of neuropathic pain. In this study, we tested whether the transfer of the glutamic acid decarboxylase (GAD) gene to dorsal root ganglion (DRG) cells would attenuate below-injury level central neuropathic pain after spinal cord injury (SCI) by using a novel human foamy virus (HFV) vector to achieve release of gamma-aminobutyric acid (GABA). Subcutaneous inoculation of a replication-defective HFV vector, which expresses GAD (vector rdvGAD67) for 7days after T13 spinal cord hemisection, reversed mechanical allodynia and thermal hyperalgesia evoked by SCI. The antiallodynic effect lasted 6 weeks and was reestablished by reinoculation. We also found that subcutaneous inoculation of rdvGAD67 resulted in enhanced production of GAD and tonical GABA release from transduced DRG neurons. These results suggest that HFV-mediated gene transfer to DRG could be employed to treat below-injury level central neuropathic pain after incomplete SCI." @default.
• W2020870274 created "2016-06-24" @default.
• W2020870274 creator A5018533685 @default.
• W2020870274 creator A5036800142 @default.
• W2020870274 creator A5047517793 @default.
• W2020870274 creator A5047988649 @default.
• W2020870274 creator A5049453966 @default.
• W2020870274 creator A5059788513 @default.
• W2020870274 creator A5061021137 @default.
• W2020870274 creator A5063481044 @default.
• W2020870274 creator A5088061646 @default.
• W2020870274 creator A5088706496 @default.
• W2020870274 date "2008-02-01" @default.
• W2020870274 modified "2023-10-17" @default.
• W2020870274 title "A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury" @default.
• W2020870274 cites W1567615855 @default.
• W2020870274 cites W1969572418 @default.
• W2020870274 cites W1970344074 @default.
• W2020870274 cites W1983697429 @default.
• W2020870274 cites W1990584664 @default.
• W2020870274 cites W1999713747 @default.
• W2020870274 cites W2010035959 @default.
• W2020870274 cites W2014007136 @default.
• W2020870274 cites W2017842089 @default.
• W2020870274 cites W2042035230 @default.
• W2020870274 cites W2045274678 @default.
• W2020870274 cites W2083171477 @default.
• W2020870274 cites W2091104634 @default.
• W2020870274 cites W2102023851 @default.
• W2020870274 cites W2165745296 @default.
• W2020870274 cites W2170645579 @default.
• W2020870274 cites W2172201406 @default.
• W2020870274 doi "https://doi.org/10.1016/j.neulet.2007.11.054" @default.
• W2020870274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18180106" @default.
• W2020870274 hasPublicationYear "2008" @default.
• W2020870274 type Work @default.
• W2020870274 sameAs 2020870274 @default.
• W2020870274 citedByCount "47" @default.
• W2020870274 countsByYear W20208702742012 @default.
• W2020870274 countsByYear W20208702742013 @default.
• W2020870274 countsByYear W20208702742015 @default.
• W2020870274 countsByYear W20208702742016 @default.
• W2020870274 countsByYear W20208702742017 @default.
• W2020870274 countsByYear W20208702742018 @default.
• W2020870274 countsByYear W20208702742019 @default.
• W2020870274 countsByYear W20208702742020 @default.
• W2020870274 countsByYear W20208702742021 @default.
• W2020870274 countsByYear W20208702742022 @default.
• W2020870274 crossrefType "journal-article" @default.
• W2020870274 hasAuthorship W2020870274A5018533685 @default.
• W2020870274 hasAuthorship W2020870274A5036800142 @default.
• W2020870274 hasAuthorship W2020870274A5047517793 @default.
• W2020870274 hasAuthorship W2020870274A5047988649 @default.
• W2020870274 hasAuthorship W2020870274A5049453966 @default.
• W2020870274 hasAuthorship W2020870274A5059788513 @default.
• W2020870274 hasAuthorship W2020870274A5061021137 @default.
• W2020870274 hasAuthorship W2020870274A5063481044 @default.
• W2020870274 hasAuthorship W2020870274A5088061646 @default.
• W2020870274 hasAuthorship W2020870274A5088706496 @default.
• W2020870274 hasConcept C118552586 @default.
• W2020870274 hasConcept C126322002 @default.
• W2020870274 hasConcept C15490471 @default.
• W2020870274 hasConcept C170493617 @default.
• W2020870274 hasConcept C181199279 @default.
• W2020870274 hasConcept C2776281502 @default.
• W2020870274 hasConcept C2777107010 @default.
• W2020870274 hasConcept C2777883359 @default.
• W2020870274 hasConcept C2778334475 @default.
• W2020870274 hasConcept C2779245659 @default.
• W2020870274 hasConcept C2780775167 @default.
• W2020870274 hasConcept C42219234 @default.
• W2020870274 hasConcept C55493867 @default.
• W2020870274 hasConcept C71924100 @default.
• W2020870274 hasConcept C86803240 @default.
• W2020870274 hasConcept C9497952 @default.
• W2020870274 hasConcept C98274493 @default.
• W2020870274 hasConceptScore W2020870274C118552586 @default.
• W2020870274 hasConceptScore W2020870274C126322002 @default.
• W2020870274 hasConceptScore W2020870274C15490471 @default.
• W2020870274 hasConceptScore W2020870274C170493617 @default.
• W2020870274 hasConceptScore W2020870274C181199279 @default.
• W2020870274 hasConceptScore W2020870274C2776281502 @default.
• W2020870274 hasConceptScore W2020870274C2777107010 @default.
• W2020870274 hasConceptScore W2020870274C2777883359 @default.
• W2020870274 hasConceptScore W2020870274C2778334475 @default.
• W2020870274 hasConceptScore W2020870274C2779245659 @default.
• W2020870274 hasConceptScore W2020870274C2780775167 @default.
• W2020870274 hasConceptScore W2020870274C42219234 @default.
• W2020870274 hasConceptScore W2020870274C55493867 @default.
• W2020870274 hasConceptScore W2020870274C71924100 @default.
• W2020870274 hasConceptScore W2020870274C86803240 @default.
• W2020870274 hasConceptScore W2020870274C9497952 @default.
• W2020870274 hasConceptScore W2020870274C98274493 @default.
• W2020870274 hasIssue "1" @default.
• W2020870274 hasLocation W20208702741 @default.
• W2020870274 hasLocation W20208702742 @default.
• W2020870274 hasOpenAccess W2020870274 @default.
• W2020870274 hasPrimaryLocation W20208702741 @default.

• next