FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020886616> ?p ?o ?g. }

• W2020886616 endingPage "118" @default.
• W2020886616 startingPage "105" @default.
• W2020886616 abstract "Porcine respiratory and reproductive syndrome virus (PRRSV) disease, one of the most economically significant viral diseases in the swine industry, is characterized by miscarriages, premature farrowing, stillborn pigs, and respiratory disease associated with death and chronic poor performance of nursing and weaned pigs. Interleukin-12 (IL-12) is a key component in driving the development of cell-mediated immunity as well as stimulating interferon-gamma (IFN-γ) production from T cells and natural killer cells. Although some studies have investigated the use of IL-12 as a vaccine adjuvant in swine, little is known about its effectiveness as a treatment against viral diseases in swine. The present study investigated whether recombinant porcine IL-12 (rpIL-12) enhances the immune response and thereby diminishes the effects of PRRSV infection in young pigs. Interestingly, in vitro experiments demonstrated that rpIL-12 is capable of inducing swine pulmonary alveolar macrophages (PAMs), the target cells of PRRSV, to produce IFN-γ in a dose and time dependent manner. In addition, in vitro studies also revealed that rpIL-12 treatment was capable of significantly reducing PRRSV viral titers in PAMs. In vivo administration of rpIL-12 significantly decreased PRRSV titers in the lungs and blood of infected animals. Furthermore, treatment with rpIL-12 prevented significant growth retardation in PRRSV-infected animals. Finally, in response to viral antigen recall challenge, PAMs isolated from rpIL-12-treated/PRRSV-infected animals produced greater amounts of IFN-γ and lesser amounts of interleukin-10 than PAMs isolated from non-rpIL-12-treated/PRRSV-infected animals. Taken together our data indicate that treatment with rpIL-12 may provide an effective approach to control or ameliorate PRRSV-induced disease in swine." @default.
• W2020886616 created "2016-06-24" @default.
• W2020886616 creator A5000324831 @default.
• W2020886616 creator A5044492497 @default.
• W2020886616 date "2005-08-01" @default.
• W2020886616 modified "2023-09-30" @default.
• W2020886616 title "Interleukin-12 (IL-12) ameliorates the effects of porcine respiratory and reproductive syndrome virus (PRRSV) infection" @default.
• W2020886616 cites W1601925808 @default.
• W2020886616 cites W1642318346 @default.
• W2020886616 cites W1751851141 @default.
• W2020886616 cites W1811961782 @default.
• W2020886616 cites W1858786069 @default.
• W2020886616 cites W1882649811 @default.
• W2020886616 cites W1972904743 @default.
• W2020886616 cites W1973990146 @default.
• W2020886616 cites W1978306909 @default.
• W2020886616 cites W1981148628 @default.
• W2020886616 cites W1985456177 @default.
• W2020886616 cites W1987786107 @default.
• W2020886616 cites W1990350083 @default.
• W2020886616 cites W1998140108 @default.
• W2020886616 cites W2006178861 @default.
• W2020886616 cites W2007379465 @default.
• W2020886616 cites W2012628280 @default.
• W2020886616 cites W2014212115 @default.
• W2020886616 cites W2021596106 @default.
• W2020886616 cites W2027005967 @default.
• W2020886616 cites W2031768490 @default.
• W2020886616 cites W2041498251 @default.
• W2020886616 cites W2044325609 @default.
• W2020886616 cites W2062591347 @default.
• W2020886616 cites W2067877107 @default.
• W2020886616 cites W2087335546 @default.
• W2020886616 cites W2095835949 @default.
• W2020886616 cites W2098128349 @default.
• W2020886616 cites W2102156468 @default.
• W2020886616 cites W2104439753 @default.
• W2020886616 cites W2105440061 @default.
• W2020886616 cites W2106196303 @default.
• W2020886616 cites W2106238650 @default.
• W2020886616 cites W2106577035 @default.
• W2020886616 cites W2117206496 @default.
• W2020886616 cites W2119969523 @default.
• W2020886616 cites W2128321311 @default.
• W2020886616 cites W2137209261 @default.
• W2020886616 cites W2150931712 @default.
• W2020886616 cites W2151925533 @default.
• W2020886616 cites W2157227966 @default.
• W2020886616 cites W2160581420 @default.
• W2020886616 cites W2197878687 @default.
• W2020886616 cites W2294807506 @default.
• W2020886616 cites W274935369 @default.
• W2020886616 doi "https://doi.org/10.1016/j.vetimm.2005.04.003" @default.
• W2020886616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15936827" @default.
• W2020886616 hasPublicationYear "2005" @default.
• W2020886616 type Work @default.
• W2020886616 sameAs 2020886616 @default.
• W2020886616 citedByCount "33" @default.
• W2020886616 countsByYear W20208866162012 @default.
• W2020886616 countsByYear W20208866162013 @default.
• W2020886616 countsByYear W20208866162014 @default.
• W2020886616 countsByYear W20208866162015 @default.
• W2020886616 countsByYear W20208866162016 @default.
• W2020886616 countsByYear W20208866162017 @default.
• W2020886616 countsByYear W20208866162018 @default.
• W2020886616 countsByYear W20208866162020 @default.
• W2020886616 countsByYear W20208866162023 @default.
• W2020886616 crossrefType "journal-article" @default.
• W2020886616 hasAuthorship W2020886616A5000324831 @default.
• W2020886616 hasAuthorship W2020886616A5044492497 @default.
• W2020886616 hasConcept C105702510 @default.
• W2020886616 hasConcept C159047783 @default.
• W2020886616 hasConcept C203014093 @default.
• W2020886616 hasConcept C2522874641 @default.
• W2020886616 hasConcept C2776178377 @default.
• W2020886616 hasConcept C2777371288 @default.
• W2020886616 hasConcept C2777863537 @default.
• W2020886616 hasConcept C2779341262 @default.
• W2020886616 hasConcept C2779819720 @default.
• W2020886616 hasConcept C534529494 @default.
• W2020886616 hasConcept C86803240 @default.
• W2020886616 hasConcept C8891405 @default.
• W2020886616 hasConceptScore W2020886616C105702510 @default.
• W2020886616 hasConceptScore W2020886616C159047783 @default.
• W2020886616 hasConceptScore W2020886616C203014093 @default.
• W2020886616 hasConceptScore W2020886616C2522874641 @default.
• W2020886616 hasConceptScore W2020886616C2776178377 @default.
• W2020886616 hasConceptScore W2020886616C2777371288 @default.
• W2020886616 hasConceptScore W2020886616C2777863537 @default.
• W2020886616 hasConceptScore W2020886616C2779341262 @default.
• W2020886616 hasConceptScore W2020886616C2779819720 @default.
• W2020886616 hasConceptScore W2020886616C534529494 @default.
• W2020886616 hasConceptScore W2020886616C86803240 @default.
• W2020886616 hasConceptScore W2020886616C8891405 @default.
• W2020886616 hasIssue "1-2" @default.
• W2020886616 hasLocation W20208866161 @default.
• W2020886616 hasLocation W20208866162 @default.
• W2020886616 hasOpenAccess W2020886616 @default.

• next