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• W2020888843 abstract "Duchenne muscular dystrophy (DMD) is characterized by the absence of dystrophin and an elevated intracellular calcium level. Single-channel recordings were performed with the cell-attached configuration of the patch-clamp technique. The present study shows, on human co-cultured normal and dystrophic muscle cells, the evidence for an increased activity of calcium permeant cationic mechano-sensitive channels under hypotonic medium stimulation. This activity was particularly enhanced in DMD cells. The hypotonic medium induced drastic changes in the single-channel activity characteristics, which are: a large increase of the calcium over potassium permeability ratio; and a great enhancement of the quantity of current crossing through these channels. These channels could contribute to a significant calcium entry, which could participate in the abnormal calcium homeostasis observed in DMD muscle." @default.
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• W2020888843 date "2002-05-01" @default.
• W2020888843 modified "2023-10-10" @default.
• W2020888843 title "Hypotonic medium increases calcium permeant channels activity in human normal and dystrophic myotubes" @default.
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• W2020888843 doi "https://doi.org/10.1016/s0304-3940(02)00148-9" @default.
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