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• W2020889330 abstract "Boronic acid affinity gels are important for effective separation of biological active cis-diols, and are finding applications both in biotech industry and in biomedical research areas. To increase the efficacy of boronate affinity separation, it is interesting to introduce repeating boronic acid units in flexible polymer chains attached on solid materials. In this work, we synthesize polymer brushes containing boronic acid repeating units on silica gels using surface-initiated atom transfer radical polymerization (ATRP). A fluorescent boronic acid monomer is first prepared from an azide-tagged fluorogenic boronic acid and an alkyne-containing acrylate by Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction (the CuAAC click chemistry). The boronic acid monomer is then grafted to the surface of silica gel modified with an ATRP initiator. The obtained composite material contains boronic acid polymer brushes on surface and shows favorable saccharide binding capability under physiological pH conditions, and displays interesting fluorescence intensity change upon binding fructose and glucose. In addition to saccharide binding, the flexible polymer brushes on silica also enable fast separation of a model glycoprotein based on selective boronate affinity interaction. The synthetic approach and the composite functional material developed in this work should open new opportunities for high efficiency detection, separation, and analysis of not only simple saccharides, but also glycopeptides and large glycoproteins." @default.
• W2020889330 created "2016-06-24" @default.
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• W2020889330 date "2014-01-28" @default.
• W2020889330 modified "2023-09-27" @default.
• W2020889330 title "Fluorescent Boronic Acid Polymer Grafted on Silica Particles for Affinity Separation of Saccharides" @default.
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• W2020889330 doi "https://doi.org/10.1021/am405531n" @default.
• W2020889330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3963438" @default.
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