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- W2020891014 abstract "The reported incidence of nuchal cord varies from 20-40%. This common finding has been associated with adverse perinatal outcomes including spastic cerebral palsy. It has been theorized that chronic intermittent hypoxia during pregnancy may predispose to the fetus to development of spastic quadriplegia. Hypoxia provides a physiological signal to increase angiogenesis and the production of erythrocytes. Therefore we hypothesized that chronic intermittent hypoxia associated with a nuchal cord would be associated with alterations in the production of vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and erythropoietin (EPO) in cord blood. Cord blood was collected after delivery as a part of our universal sampling procedures with IRB oversight. Samples from fetuses with a nuchal cord (n = 13) and those without (n = 15) were collected into EDTA tubes and plasma was harvested by centrifugation and stored at -85°C until assay for EPO, VEGF and PlGF. Data were evaluated using t tests. No significant differences were detected between VEGF, PlGF and EPO concentrations in cord blood between babies born with nuchal and normal cords (Table). The presence of a nuchal cord has no effect on cord blood concentrations of VEGF, PlGF or EPO. This observation does not support the concept that long-term fetal hypoxia is present in pregnancies complicated by nuchal cord. Future prospective investigation is planned focusing on the same markers of hypoxia and angiogenesis in fetuses who are identified sonographically as having a nuchal cord in the antenatal period, rather than limiting the study group to those with a nuchal cord at delivery.Tabled 1Cord blood hormone concentrationsHormone (units)Control (mean ± SEM)Nuchal cord (mean ± SEM)P valueVEGF (pg/mL)1114.0 ± 390.9566.7 ± 296.7.2800PlGF (pg/mL)61.8 ± 5.57292.4 ± 240.92.3705EPO (mIU/mL)33.9 ± 5.9339.4 ± 11.0.6618 Open table in a new tab" @default.
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- W2020891014 date "2004-12-01" @default.
- W2020891014 modified "2023-09-25" @default.
- W2020891014 title "Markers of chronic hypoxia in pregnancies complicated by nuchal cord" @default.
- W2020891014 doi "https://doi.org/10.1016/j.ajog.2004.10.368" @default.
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