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- W202089918 abstract "5-HT3 receptor antagonists, ondansetron, granlsetron and tropisetron are highly specific for the 5-HT3 receptor and have a selectivity ratio of approximately 1000:1 compared with affinities for other receptors. Other 5-HT3 receptor antagonists, largely those having a benzamlde structure, are non-selective. These Include metoclopramide, renzapride and zacoprlde which stimulate gastric motility via activation of 5-HT4 receptors; metoclopramide is also a potent dopamine receptor antagonist. Selective 5-HT3 receptor antagonists are a major advance in the treatment of chemotherapy- and radiotherapy-induced emesls In cancer patients. These agents Inhibit emesls by blocking 5-HT3 receptors on vagal afferent nerve terminals in the gastrointestinal mucosa and on terminals on the same vagal nerves In the vomiting system. Inhibition of acute emesls appears to be produced by blocking the Initiation of the emetic reflex Induced via 5-HT3 receptors and by 5-HT released from enterochromaffin cells in the small intestine, as well as by blocking 5-HT3 receptors In the hlndbraln vomiting system." @default.
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- W202089918 doi "https://doi.org/10.1097/00001813-199204000-00001" @default.
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