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- W2020907532 abstract "In the present study, we developed a high-throughput screening system for small molecule-inhibitors of the basic helix-loop-helix (bHLH) transcriptional repressor factor Hes1. Successful dimerization of Hes1 immobilized on a microplate and fluorophore (Cy3)-labelled Hes1 was confirmed. Using this system, several natural products were identified as the first Hes1 dimer inhibitors. Of these, two compounds which were isolated from myxomycetes (true slime molds) inhibited Hes1 from N box-dependent suppression of the gene expression in C3H10T1/2 cells." @default.
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- W2020907532 date "2009-10-01" @default.
- W2020907532 modified "2023-10-14" @default.
- W2020907532 title "The first Hes1 dimer inhibitors from natural products" @default.
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- W2020907532 doi "https://doi.org/10.1016/j.bmcl.2009.07.146" @default.
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