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• W2020919212 abstract "Mouse peritoneal macrophages, obtained by lavage and cultured for 24–72 hr in media 199, were exposed to several concentrations of dead, freeze-dried plaque for various time periods. The presence of plaque concentrations of 1–20 μg/ml led to a 3–4-fold increase in cell size and in the content of lactate dehydrogenase and leucine-2-naphthylamidase, and to a doubling in the levels of beta-glucuronidase. These are features of cell activation. Furthermore, plaque induced a marked and selective release of lysosomal enzymes into the culture media. Up to 80 per cent of the total hydrolase present was released. If a similar release of hydrolases from macrophages occurs within the gingiva in response to plaque, wide-spread long-term tissue damage would be expected. Des macrophages péritonéaux de souris, obtenus par lavage et par mise en culture de 24 à 72 h dans le milieu 199, sont soumis à différentes concentrations de plaque tuée et lyophilisée, pendant des périodes variables. La présence de concentrations de plaque de 1 à 20 μg/ml correspond à une augmentation par 3 ou 4 de la taille des cellules ainsi que du contenu en lactate deshydrogénase et leucine-2-naphthylamidase. Les concentrations en β-glucuronidase doublent. Ces divers faits sont des arguments en faveur d'une activation cellulaire. De plus, la plaque induit un rejet marqué et sélectif d'enzymes lysosomiales dans le milieu de culture. Jusqu'à 80 pour cent d'hydrolase totale peut être rejetée. Si un rejet identique d'hydrolase des macrophages se produit dans la gencive, sous l'action de la plaque, des dégats tissulaires durables sont possibles. Durch Spülung und 24 bis 72 Std dauernde Kultivierung in Medium 199 gewonnene Peritonealmacrophagen der Maus wurden abgetöteter, gefriergetrockneter Plaque in mehreren Konzentrationen über verschiedew lange Zeit ausgesetzt. Plaquekonzentrationen zwischen 1 und 20 μg/ml führen zu einer Steigerung der Zellgröβe auf das Drei- bis Vierfache und zu einer gleichartigen Steigerung der Lactatdehydrogenase und Leucin-2-naphthylamidase sowie einer Verdoppelung der β-Glucuronidase. Diese Erscheinungen sind Ausdruck der Zellaktivierung. Darüber hinaus induziert Plaque eine deutliche und selektive Freisetzung lysosomaler Enzyme in das Kulturmedium. Bis zu 80 Prozent der gesamten vorhandenen Hydrolasen können freigesetzt werden. Wenn eine ähnliche Freisetzung der Hydrolasen aus Makrophagen in der Gingiva als Reaktion auf Plaques zustande kommt, wäre ein ausgedehnter langfristiger Gewebsschaden zu erwarten." @default.
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• W2020919212 date "1973-12-01" @default.
• W2020919212 modified "2023-09-27" @default.
• W2020919212 title "Effects of dental plaque on the production and release of lysosomal hydrolases by macrophages in culture" @default.
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• W2020919212 doi "https://doi.org/10.1016/0003-9969(73)90124-6" @default.
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