Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020921331> ?p ?o ?g. }
- W2020921331 endingPage "1800" @default.
- W2020921331 startingPage "1749" @default.
- W2020921331 abstract "Snake venoms are complex mixtures containing many different biologically active proteins and peptides. A number of these proteins interact with components of the human hemostatic system. This review is focused on those venom constituents which affect the blood coagulation pathway, endothelial cells, and platelets. Only highly purified and well characterized snake venom proteins will be discussed in this review. Hemostatically active components are distributed widely in the venom of many different snake species, particularly from pit viper, viper and elapid venoms. The venom components can be grouped into a number of different categories depending on their hemostatic action. The following groups are discussed in this review: (i) enzymes that clot fibrinogen; (ii) enzymes that degrade fibrin(ogen); (iii) plasminogen activators; (iv) prothrombin activators; (v) factor V activators; (vi) factor X activators; (vii) anticoagulant activities including inhibitors of prothrombinase complex formation, inhibitors of thrombin, phospholipases, and protein C activators; (viii) enzymes with hemorrhagic activity; (ix) enzymes that degrade plasma serine proteinase inhibitors; (x) platelet aggregation inducers including direct acting enzymes, direct acting non-enzymatic components, and agents that require a cofactor; (xi) platelet aggregation inhibitors including: alpha-fibrinogenases, 5'-nucleotidases, phospholipases, and disintegrins. Although many snake venoms contain a number of hemostatically active components, it is safe to say that no single venom contains all the hemostatically active components described here. Several venom enzymes have been used clinically as anticoagulants and other venom components are being used in pre-clinical research to examine their possible therapeutic potential. The disintegrins are an interesting group of peptides that contain a cell adhesion recognition motif, Arg-Gly-Asp (RGD), in the carboxy-terminal half of their amino acid sequence. These agents act as fibrinogen receptor (integrin GPIIb/IIIa) antagonists. Since this integrin is believed to serve as the final common pathway leading to the formation of platelet-platelet bridges and platelet aggregation, blockage of this integrin leads to inhibition of platelet aggregation regardless of the stimulating agent. Clinical trials suggest that platelet GPIIb/IIIa blockade is an effective therapy for the thrombotic events and restenosis frequently accompanying cardiovascular and cerebrovascular disease. Therefore, because of their clinical poten tial, a large number of disintegrins have been isolated and characterized." @default.
- W2020921331 created "2016-06-24" @default.
- W2020921331 creator A5054474510 @default.
- W2020921331 date "1998-12-01" @default.
- W2020921331 modified "2023-10-09" @default.
- W2020921331 title "Snake venoms and the hemostatic system" @default.
- W2020921331 cites W1020740103 @default.
- W2020921331 cites W1483040869 @default.
- W2020921331 cites W1486209432 @default.
- W2020921331 cites W1498284743 @default.
- W2020921331 cites W1514985534 @default.
- W2020921331 cites W1529569975 @default.
- W2020921331 cites W1532085934 @default.
- W2020921331 cites W1535173945 @default.
- W2020921331 cites W1536436305 @default.
- W2020921331 cites W1541525472 @default.
- W2020921331 cites W1542724925 @default.
- W2020921331 cites W1543555923 @default.
- W2020921331 cites W1546663611 @default.
- W2020921331 cites W1549450967 @default.
- W2020921331 cites W1560153159 @default.
- W2020921331 cites W1574819209 @default.
- W2020921331 cites W1576992065 @default.
- W2020921331 cites W1591954937 @default.
- W2020921331 cites W160134079 @default.
- W2020921331 cites W1608689063 @default.
- W2020921331 cites W161576220 @default.
- W2020921331 cites W1623093344 @default.
- W2020921331 cites W1627718954 @default.
- W2020921331 cites W1688255783 @default.
- W2020921331 cites W1705854607 @default.
- W2020921331 cites W174279387 @default.
- W2020921331 cites W17573038 @default.
- W2020921331 cites W182036647 @default.
- W2020921331 cites W1821071109 @default.
- W2020921331 cites W1835135188 @default.
- W2020921331 cites W1838407374 @default.
- W2020921331 cites W1871618339 @default.
- W2020921331 cites W1877758911 @default.
- W2020921331 cites W1880926063 @default.
- W2020921331 cites W1906324427 @default.
- W2020921331 cites W1942443265 @default.
- W2020921331 cites W1965520907 @default.
- W2020921331 cites W1967720238 @default.
- W2020921331 cites W1968411344 @default.
- W2020921331 cites W1968574939 @default.
- W2020921331 cites W1968861934 @default.
- W2020921331 cites W1969038707 @default.
- W2020921331 cites W1969945782 @default.
- W2020921331 cites W1970234703 @default.
- W2020921331 cites W1970325189 @default.
- W2020921331 cites W1971879774 @default.
- W2020921331 cites W1972074907 @default.
- W2020921331 cites W1975003475 @default.
- W2020921331 cites W1976767749 @default.
- W2020921331 cites W1977371464 @default.
- W2020921331 cites W1978195698 @default.
- W2020921331 cites W1978289150 @default.
- W2020921331 cites W1978947433 @default.
- W2020921331 cites W1979539758 @default.
- W2020921331 cites W1981086573 @default.
- W2020921331 cites W1981102616 @default.
- W2020921331 cites W1982164669 @default.
- W2020921331 cites W1982797973 @default.
- W2020921331 cites W1983837266 @default.
- W2020921331 cites W1984441154 @default.
- W2020921331 cites W1985981054 @default.
- W2020921331 cites W1987960747 @default.
- W2020921331 cites W1989249879 @default.
- W2020921331 cites W1989687091 @default.
- W2020921331 cites W1989925537 @default.
- W2020921331 cites W1991063206 @default.
- W2020921331 cites W1991530649 @default.
- W2020921331 cites W1991732293 @default.
- W2020921331 cites W1992001552 @default.
- W2020921331 cites W1992050687 @default.
- W2020921331 cites W1992556027 @default.
- W2020921331 cites W1993586213 @default.
- W2020921331 cites W1998404570 @default.
- W2020921331 cites W1999977425 @default.
- W2020921331 cites W2000772110 @default.
- W2020921331 cites W2001716682 @default.
- W2020921331 cites W2004606612 @default.
- W2020921331 cites W2004712660 @default.
- W2020921331 cites W2004896547 @default.
- W2020921331 cites W2004941257 @default.
- W2020921331 cites W2005462877 @default.
- W2020921331 cites W2007067269 @default.
- W2020921331 cites W2008034589 @default.
- W2020921331 cites W2008401688 @default.
- W2020921331 cites W2008745453 @default.
- W2020921331 cites W2009479027 @default.
- W2020921331 cites W2009942259 @default.
- W2020921331 cites W2010146383 @default.
- W2020921331 cites W2010963716 @default.
- W2020921331 cites W2011105427 @default.
- W2020921331 cites W2011533896 @default.
- W2020921331 cites W2012499228 @default.