Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020942562> ?p ?o ?g. }
- W2020942562 endingPage "1884" @default.
- W2020942562 startingPage "1875" @default.
- W2020942562 abstract "One of the most striking 'rags to riches' stories in the protein world is that of 14-3-3, originally identified in 1967 as merely an abundant brain protein. The first clues that 14-3-3 would play an important role in cell biology came almost 25 years later when it was found to interact with various proto-oncogene proteins and signaling proteins. The subsequent identification of 14-3-3 as a phosphoserine/phosphothreonine-binding protein firmly established its importance in cell signaling. 14-3-3 family members are found in all eukaryotes - from plants to mammals - and more than 100 binding partners have been identified to date. The targets of 14-3-3 are found in all subcellular compartments and their functional diversity is overwhelming - they include transcription factors, biosynthetic enzymes, cytoskeletal proteins, signaling molecules, apoptosis factors and tumor suppressors. 14-3-3 binding can alter the localization, stability, phosphorylation state, activity and/or molecular interactions of a target protein. Recent studies now indicate that the serine/threonine protein phosphatases PP1 and PP2A are important regulators of 14-3-3 binding interactions, and demonstrate a role for 14-3-3 in controlling the translocation of certain proteins from the cytoplasmic and endoplasmic reticulum to the plasma membrane. New reports also link 14-3-3 to several neoplastic and neurological disorders, where it might contribute to the pathogenesis and progression of these diseases." @default.
- W2020942562 created "2016-06-24" @default.
- W2020942562 creator A5033225529 @default.
- W2020942562 creator A5061515984 @default.
- W2020942562 date "2004-04-15" @default.
- W2020942562 modified "2023-10-14" @default.
- W2020942562 title "Unlocking the code of 14-3-3" @default.
- W2020942562 cites W1495729285 @default.
- W2020942562 cites W1501075116 @default.
- W2020942562 cites W1518401857 @default.
- W2020942562 cites W1527671059 @default.
- W2020942562 cites W1530609782 @default.
- W2020942562 cites W1569055397 @default.
- W2020942562 cites W1606911600 @default.
- W2020942562 cites W1790773213 @default.
- W2020942562 cites W1847155226 @default.
- W2020942562 cites W1850214287 @default.
- W2020942562 cites W1964237296 @default.
- W2020942562 cites W1967255508 @default.
- W2020942562 cites W1968214041 @default.
- W2020942562 cites W1971374487 @default.
- W2020942562 cites W1972978932 @default.
- W2020942562 cites W1973049520 @default.
- W2020942562 cites W1974250989 @default.
- W2020942562 cites W197448336 @default.
- W2020942562 cites W1975689520 @default.
- W2020942562 cites W1976345822 @default.
- W2020942562 cites W1976728998 @default.
- W2020942562 cites W1977747566 @default.
- W2020942562 cites W1978406914 @default.
- W2020942562 cites W1978535713 @default.
- W2020942562 cites W1978668412 @default.
- W2020942562 cites W1979331393 @default.
- W2020942562 cites W1984335236 @default.
- W2020942562 cites W1987826022 @default.
- W2020942562 cites W1990283596 @default.
- W2020942562 cites W1995515835 @default.
- W2020942562 cites W1996818295 @default.
- W2020942562 cites W1998879017 @default.
- W2020942562 cites W2002370642 @default.
- W2020942562 cites W2005500718 @default.
- W2020942562 cites W2007486260 @default.
- W2020942562 cites W2009516619 @default.
- W2020942562 cites W2011818472 @default.
- W2020942562 cites W2013452582 @default.
- W2020942562 cites W2014815147 @default.
- W2020942562 cites W2021207380 @default.
- W2020942562 cites W2021538852 @default.
- W2020942562 cites W2022161594 @default.
- W2020942562 cites W2023397454 @default.
- W2020942562 cites W2023819606 @default.
- W2020942562 cites W2024880806 @default.
- W2020942562 cites W2024923170 @default.
- W2020942562 cites W2026856916 @default.
- W2020942562 cites W2027594237 @default.
- W2020942562 cites W2029479878 @default.
- W2020942562 cites W2029810183 @default.
- W2020942562 cites W2030041656 @default.
- W2020942562 cites W2030573603 @default.
- W2020942562 cites W2034756429 @default.
- W2020942562 cites W2043028254 @default.
- W2020942562 cites W2044481116 @default.
- W2020942562 cites W2046323443 @default.
- W2020942562 cites W2048168473 @default.
- W2020942562 cites W2051926432 @default.
- W2020942562 cites W2052159338 @default.
- W2020942562 cites W2056137479 @default.
- W2020942562 cites W2061216192 @default.
- W2020942562 cites W2061425356 @default.
- W2020942562 cites W2062541978 @default.
- W2020942562 cites W2069512007 @default.
- W2020942562 cites W2071075259 @default.
- W2020942562 cites W2072529095 @default.
- W2020942562 cites W2074489870 @default.
- W2020942562 cites W2076314401 @default.
- W2020942562 cites W2077230170 @default.
- W2020942562 cites W2077452823 @default.
- W2020942562 cites W2077895194 @default.
- W2020942562 cites W2078913984 @default.
- W2020942562 cites W2082853003 @default.
- W2020942562 cites W2082868411 @default.
- W2020942562 cites W2082974905 @default.
- W2020942562 cites W2083240338 @default.
- W2020942562 cites W2084290625 @default.
- W2020942562 cites W2085381292 @default.
- W2020942562 cites W2085462220 @default.
- W2020942562 cites W2087697646 @default.
- W2020942562 cites W2092904031 @default.
- W2020942562 cites W2093628776 @default.
- W2020942562 cites W2094537612 @default.
- W2020942562 cites W2100322860 @default.
- W2020942562 cites W2102233623 @default.
- W2020942562 cites W2103377960 @default.
- W2020942562 cites W2105016405 @default.
- W2020942562 cites W2105592350 @default.
- W2020942562 cites W2107389581 @default.
- W2020942562 cites W2109263914 @default.
- W2020942562 cites W2112879240 @default.