FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020943564> ?p ?o ?g. }

• W2020943564 endingPage "328" @default.
• W2020943564 startingPage "324" @default.
• W2020943564 abstract "Vaccine design is challenging when the infectious agent is genetically diverse. Polyvalent 'mosaic' antigens might be used to address this challenge, and these two studies show promising results in monkeys infected with HIV-1 ( pages 268–270 and pages 319–323 ). An effective HIV vaccine must elicit immune responses that recognize genetically diverse viruses1,2. It must generate CD8+ T lymphocytes that control HIV replication and CD4+ T lymphocytes that provide help for the generation and maintenance of both cellular and humoral immune responses against the virus3,4,5. Creating immunogens that can elicit cellular immune responses against the genetically varied circulating isolates of HIV presents a key challenge for creating an HIV vaccine6,7. Polyvalent mosaic immunogens derived by in silico recombination of natural strains of HIV are designed to induce cellular immune responses that recognize genetically diverse circulating virus isolates8. Here we immunized rhesus monkeys by plasmid DNA prime and recombinant vaccinia virus boost with vaccine constructs expressing either consensus or polyvalent mosaic proteins. As compared to consensus immunogens, the mosaic immunogens elicited CD8+ T lymphocyte responses to more epitopes of each viral protein than did the consensus immunogens and to more variant sequences of CD8+ T lymphocyte epitopes. This increased breadth and depth of epitope recognition may contribute both to protection against infection by genetically diverse viruses and to the control of variant viruses that emerge as they mutate away from recognition by cytotoxic T lymphocytes." @default.
• W2020943564 created "2016-06-24" @default.
• W2020943564 creator A5006205918 @default.
• W2020943564 creator A5009364817 @default.
• W2020943564 creator A5013669743 @default.
• W2020943564 creator A5022985881 @default.
• W2020943564 creator A5030542413 @default.
• W2020943564 creator A5030798404 @default.
• W2020943564 creator A5032122826 @default.
• W2020943564 creator A5043536622 @default.
• W2020943564 creator A5048037773 @default.
• W2020943564 creator A5051827275 @default.
• W2020943564 creator A5052937275 @default.
• W2020943564 creator A5054928376 @default.
• W2020943564 creator A5056634574 @default.
• W2020943564 creator A5062495915 @default.
• W2020943564 creator A5066261446 @default.
• W2020943564 creator A5069687616 @default.
• W2020943564 creator A5072737624 @default.
• W2020943564 creator A5075957872 @default.
• W2020943564 creator A5084461087 @default.
• W2020943564 creator A5084520422 @default.
• W2020943564 date "2010-02-21" @default.
• W2020943564 modified "2023-10-17" @default.
• W2020943564 title "Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys" @default.
• W2020943564 cites W1570511160 @default.
• W2020943564 cites W1993846907 @default.
• W2020943564 cites W1994048581 @default.
• W2020943564 cites W2013815517 @default.
• W2020943564 cites W2015125044 @default.
• W2020943564 cites W2017809447 @default.
• W2020943564 cites W2029043430 @default.
• W2020943564 cites W2070491512 @default.
• W2020943564 cites W2074751153 @default.
• W2020943564 cites W2075227408 @default.
• W2020943564 cites W2087866505 @default.
• W2020943564 cites W2097771941 @default.
• W2020943564 cites W2118222952 @default.
• W2020943564 cites W2136554163 @default.
• W2020943564 cites W2153163225 @default.
• W2020943564 cites W2162891851 @default.
• W2020943564 cites W2168188696 @default.
• W2020943564 cites W4210762088 @default.
• W2020943564 doi "https://doi.org/10.1038/nm.2108" @default.
• W2020943564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2834806" @default.
• W2020943564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20173754" @default.
• W2020943564 hasPublicationYear "2010" @default.
• W2020943564 type Work @default.
• W2020943564 sameAs 2020943564 @default.
• W2020943564 citedByCount "214" @default.
• W2020943564 countsByYear W20209435642012 @default.
• W2020943564 countsByYear W20209435642013 @default.
• W2020943564 countsByYear W20209435642014 @default.
• W2020943564 countsByYear W20209435642015 @default.
• W2020943564 countsByYear W20209435642016 @default.
• W2020943564 countsByYear W20209435642017 @default.
• W2020943564 countsByYear W20209435642018 @default.
• W2020943564 countsByYear W20209435642019 @default.
• W2020943564 countsByYear W20209435642020 @default.
• W2020943564 countsByYear W20209435642021 @default.
• W2020943564 countsByYear W20209435642022 @default.
• W2020943564 countsByYear W20209435642023 @default.
• W2020943564 crossrefType "journal-article" @default.
• W2020943564 hasAuthorship W2020943564A5006205918 @default.
• W2020943564 hasAuthorship W2020943564A5009364817 @default.
• W2020943564 hasAuthorship W2020943564A5013669743 @default.
• W2020943564 hasAuthorship W2020943564A5022985881 @default.
• W2020943564 hasAuthorship W2020943564A5030542413 @default.
• W2020943564 hasAuthorship W2020943564A5030798404 @default.
• W2020943564 hasAuthorship W2020943564A5032122826 @default.
• W2020943564 hasAuthorship W2020943564A5043536622 @default.
• W2020943564 hasAuthorship W2020943564A5048037773 @default.
• W2020943564 hasAuthorship W2020943564A5051827275 @default.
• W2020943564 hasAuthorship W2020943564A5052937275 @default.
• W2020943564 hasAuthorship W2020943564A5054928376 @default.
• W2020943564 hasAuthorship W2020943564A5056634574 @default.
• W2020943564 hasAuthorship W2020943564A5062495915 @default.
• W2020943564 hasAuthorship W2020943564A5066261446 @default.
• W2020943564 hasAuthorship W2020943564A5069687616 @default.
• W2020943564 hasAuthorship W2020943564A5072737624 @default.
• W2020943564 hasAuthorship W2020943564A5075957872 @default.
• W2020943564 hasAuthorship W2020943564A5084461087 @default.
• W2020943564 hasAuthorship W2020943564A5084520422 @default.
• W2020943564 hasBestOaLocation W20209435641 @default.
• W2020943564 hasConcept C104317684 @default.
• W2020943564 hasConcept C147483822 @default.
• W2020943564 hasConcept C154317977 @default.
• W2020943564 hasConcept C159047783 @default.
• W2020943564 hasConcept C159654299 @default.
• W2020943564 hasConcept C167508917 @default.
• W2020943564 hasConcept C167672396 @default.
• W2020943564 hasConcept C195616568 @default.
• W2020943564 hasConcept C202751555 @default.
• W2020943564 hasConcept C203014093 @default.
• W2020943564 hasConcept C22070199 @default.
• W2020943564 hasConcept C2522874641 @default.
• W2020943564 hasConcept C2777760223 @default.
• W2020943564 hasConcept C2778190748 @default.

• next