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• W2020946319 abstract "<h3>Objective:</h3> Recent studies demonstrate significant thinning of the retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) non–optic neuritis (MS-NON) eyes. However, the pathologic basis of this reduction is not clear. The aim of the current study was to investigate the relationship of the RNFL thickness in MS-NON eyes with latency delay of the multifocal visual evoked potential (mfVEP), a surrogate marker of the visual pathway demyelination. <h3>Methods:</h3> Total and temporal RNFL thickness and latency of the mfVEP in 45 MS-NON eyes of 45 patients with relapsing-remitting MS and 25 eyes of age- and gender-matched controls were measured and analyzed. <h3>Results:</h3> There was significant reduction of total and temporal RNFL thickness (<i>p</i> = 0.015 and <i>p</i> = 0.006, respectively) and significant latency delay (<i>p</i> < 0.0001) in MS-NON eyes. Both total and temporal RNFL thickness were associated with latency of the mfVEP (<i>r</i>² = 0.43, <i>p</i> < 0.0001 and <i>r</i>² = 0.36, <i>p</i> = 0.001, respectively). MS-NON eyes with normal latency (n = 26) showed no significant reduction of RNFL thickness compared with controls (<i>p</i> = 0.44 and <i>p</i> = 0.1 for total and temporal RNFL, respectively), whereas eyes with delayed latency (n = 19) demonstrated significantly thinner RNFL (<i>p</i> = 0.001 and <i>p</i> = 0.0005). MS-NON eyes with delayed latency also had significantly thinner RNFL compared with those with normal latencies (<i>p</i> = 0.013 and <i>p</i> = 0.02). In patients with no previous optic neuritis in either eye, delayed latency and reduced RNFL were bilateral whenever present. <h3>Conclusions:</h3> The study demonstrated significant association between RNFL loss and a latency delay of the mfVEP in MS-NON eyes." @default.
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• W2020946319 date "2012-12-26" @default.
• W2020946319 modified "2023-10-14" @default.
• W2020946319 title "Axonal loss in non-optic neuritis eyes of patients with multiple sclerosis linked to delayed visual evoked potential" @default.
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• W2020946319 doi "https://doi.org/10.1212/wnl.0b013e31827deb39" @default.
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