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- W2020947315 abstract "An electrochemical biosensor was developed for the label-free and selective detection of leukemia cells based on aptamer-modified gold electrode using electrochemical impedance spectroscopy (EIS) technique. The thiol-terminated aptamer (sgc8c) selected for CCRF-CEM acute leukemia cells was self-assembled onto the gold electrode surface as recognition probe, which was characterized by cyclic voltammetry (CV) and EIS using Fe(CN)63−/4− as a redox probe. The surface density of aptamers was determined by chronocoulometric method using a redox cation of Ru(NH3)63+. Upon incubation of the aptamer-modified electrode with CCRF-CEM cells, the electron-transfer resistance (Ret) of Fe(CN)63−/4− on the sensor surface increased substantially. Only a small Ret change of the sensor to the control negative cell line RAJI was observed, indicating the excellent selectivity of the sensor. The selective capture of CCRF-CEM cells on the sensor surface was also confirmed by fluorescence microscopy. A linear relationship between Ret and the logarithmic value of CCRF-CEM cells concentration was found in the range of 1×104 to 1×107 cells/mL, with a detection limit of 6×103 cells/mL. This work provided a simple, convenient, low-cost and label-free method for early leukemia diagnosis." @default.
- W2020947315 created "2016-06-24" @default.
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- W2020947315 date "2009-06-01" @default.
- W2020947315 modified "2023-09-26" @default.
- W2020947315 title "Aptamer-Based Electrochemical Sensor for Label-Free Recognition and Detection of Cancer Cells" @default.
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- W2020947315 doi "https://doi.org/10.1002/elan.200804563" @default.
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