FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020954363> ?p ?o ?g. }

• W2020954363 abstract "Raf is one of the downstream effectors of Ras GTPases. The induction of Raf in the epidermis causes the proliferation of keratinocytes and epidermal hyperplasia. However, skin inflammation accompanying Ras-induced epidermal reactions has not been fully delineated.The aim of this study was to characterize inflammatory reactions induced by epidermal-specific Raf expression and to elucidate its role in skin inflammation.K14-Raf:ER transgenic mice, in which the 4-hydroxytamoxifen (4OHT)-responsive mutant estrogen receptor (ER) ligand binding domain-Raf fusion gene was expressed under control of the keratin 14 promoter, were used to characterize inflammatory reactions induced by Raf expression in the epidermis.A single topical application of 4OHT induced the expression of phosphorylated extracellular signal-related kinase 1/2 and elicited neutrophil-dominant inflammatory infiltrates in the skin. The Raf expression also rapidly induced the production of several cytokines and chemokines, including VEGF and CXCL1, by keratinocytes and inmouse skin in vivo. Furthermore, CD4-positive cells from regional lymph nodes had the potential to differentiate into IFNg- and IL17-producing cells. Treatment with an anti-Gr-1 antibody diminished the Raf-induced cutaneous inflammation and partially reversed the epidermal hyperplasia and hyperkeratosis.Activation of the Raf signaling pathway is involved in the epidermal hyperplasia and the neutrophil-dominant cutaneous inflammatory reactions which are characteristics of psoriasis." @default.
• W2020954363 created "2016-06-24" @default.
• W2020954363 creator A5005867340 @default.
• W2020954363 creator A5026667312 @default.
• W2020954363 creator A5041585341 @default.
• W2020954363 creator A5042837796 @default.
• W2020954363 creator A5049211831 @default.
• W2020954363 creator A5063112762 @default.
• W2020954363 date "2010-07-01" @default.
• W2020954363 modified "2023-10-04" @default.
• W2020954363 title "Erratum to “Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice” [J. Dermatol. Sci. 58 (2010) 28–35]" @default.
• W2020954363 cites W1480556965 @default.
• W2020954363 cites W1967944520 @default.
• W2020954363 cites W1993273784 @default.
• W2020954363 cites W1999441881 @default.
• W2020954363 cites W2000076767 @default.
• W2020954363 cites W2017987372 @default.
• W2020954363 cites W2038264502 @default.
• W2020954363 cites W2054037320 @default.
• W2020954363 cites W2058672282 @default.
• W2020954363 cites W2062210994 @default.
• W2020954363 cites W2070800665 @default.
• W2020954363 cites W2071343804 @default.
• W2020954363 cites W2073037264 @default.
• W2020954363 cites W2074360288 @default.
• W2020954363 cites W2078459253 @default.
• W2020954363 cites W2079850201 @default.
• W2020954363 cites W2080090843 @default.
• W2020954363 cites W2086296240 @default.
• W2020954363 cites W2106577067 @default.
• W2020954363 cites W2118378313 @default.
• W2020954363 cites W2123679910 @default.
• W2020954363 cites W2131239942 @default.
• W2020954363 cites W2133407324 @default.
• W2020954363 cites W2140118273 @default.
• W2020954363 cites W2146304976 @default.
• W2020954363 cites W2150732175 @default.
• W2020954363 cites W2154803358 @default.
• W2020954363 cites W2170999403 @default.
• W2020954363 cites W3021094229 @default.
• W2020954363 doi "https://doi.org/10.1016/j.jdermsci.2010.01.006" @default.
• W2020954363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20578288" @default.
• W2020954363 hasPublicationYear "2010" @default.
• W2020954363 type Work @default.
• W2020954363 sameAs 2020954363 @default.
• W2020954363 citedByCount "0" @default.
• W2020954363 crossrefType "journal-article" @default.
• W2020954363 hasAuthorship W2020954363A5005867340 @default.
• W2020954363 hasAuthorship W2020954363A5026667312 @default.
• W2020954363 hasAuthorship W2020954363A5041585341 @default.
• W2020954363 hasAuthorship W2020954363A5042837796 @default.
• W2020954363 hasAuthorship W2020954363A5049211831 @default.
• W2020954363 hasAuthorship W2020954363A5063112762 @default.
• W2020954363 hasBestOaLocation W20209543631 @default.
• W2020954363 hasConcept C105702510 @default.
• W2020954363 hasConcept C13373296 @default.
• W2020954363 hasConcept C170178370 @default.
• W2020954363 hasConcept C203014093 @default.
• W2020954363 hasConcept C204232928 @default.
• W2020954363 hasConcept C2776458125 @default.
• W2020954363 hasConcept C2776914184 @default.
• W2020954363 hasConcept C2780564577 @default.
• W2020954363 hasConcept C502942594 @default.
• W2020954363 hasConcept C71924100 @default.
• W2020954363 hasConceptScore W2020954363C105702510 @default.
• W2020954363 hasConceptScore W2020954363C13373296 @default.
• W2020954363 hasConceptScore W2020954363C170178370 @default.
• W2020954363 hasConceptScore W2020954363C203014093 @default.
• W2020954363 hasConceptScore W2020954363C204232928 @default.
• W2020954363 hasConceptScore W2020954363C2776458125 @default.
• W2020954363 hasConceptScore W2020954363C2776914184 @default.
• W2020954363 hasConceptScore W2020954363C2780564577 @default.
• W2020954363 hasConceptScore W2020954363C502942594 @default.
• W2020954363 hasConceptScore W2020954363C71924100 @default.
• W2020954363 hasLocation W20209543631 @default.
• W2020954363 hasLocation W20209543632 @default.
• W2020954363 hasOpenAccess W2020954363 @default.
• W2020954363 hasPrimaryLocation W20209543631 @default.
• W2020954363 hasRelatedWork W1745720620 @default.
• W2020954363 hasRelatedWork W1988477431 @default.
• W2020954363 hasRelatedWork W2006066882 @default.
• W2020954363 hasRelatedWork W2007467758 @default.
• W2020954363 hasRelatedWork W2011566712 @default.
• W2020954363 hasRelatedWork W2051431712 @default.
• W2020954363 hasRelatedWork W2062838126 @default.
• W2020954363 hasRelatedWork W2068093482 @default.
• W2020954363 hasRelatedWork W2094583929 @default.
• W2020954363 hasRelatedWork W2102720938 @default.
• W2020954363 hasRelatedWork W2103806424 @default.
• W2020954363 hasRelatedWork W2137570780 @default.
• W2020954363 hasRelatedWork W2142982089 @default.
• W2020954363 hasRelatedWork W2162390943 @default.
• W2020954363 hasRelatedWork W2902501734 @default.
• W2020954363 hasRelatedWork W2902843681 @default.
• W2020954363 hasRelatedWork W2954759195 @default.
• W2020954363 hasRelatedWork W2976414361 @default.
• W2020954363 hasRelatedWork W3026001769 @default.
• W2020954363 hasRelatedWork W3203757873 @default.
• W2020954363 isParatext "false" @default.
• W2020954363 isRetracted "false" @default.

• next