FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020958481> ?p ?o ?g. }

• W2020958481 endingPage "4940" @default.
• W2020958481 startingPage "4931" @default.
• W2020958481 abstract "Fibroblast growth factor 21 (FGF21) is a key metabolic regulator. Expressed primarily in liver and adipose tissue, FGF21 is induced via peroxisome proliferator-activated receptor (PPAR) pathways during states requiring increased fatty acid oxidation including fasting and consumption of a ketogenic diet. To test the hypothesis that FGF21 is a physiological regulator that plays a role in lipid oxidation, we generated mice with targeted disruption of the Fgf21 locus (FGF21 knockout). Mice lacking FGF21 had mild weight gain and slightly impaired glucose homeostasis, indicating a role in long-term energy homeostasis. Furthermore, FGF21KO mice tolerated a 24-h fast, indicating that FGF21 is not essential in the early stages of starvation. In contrast to wild-type animals in which feeding KD leads to dramatic weight loss, FGF21KO mice fed KD gained weight, developed hepatosteatosis, and showed marked impairments in ketogenesis and glucose control. This confirms the physiological importance of FGF21 in the adaptation to KD feeding. At a molecular level, these effects were accompanied by lower levels of expression of PGC1alpha and PGC1beta in FGF21KO mice, strongly implicating these key transcriptional regulators in the action of FGF21. Furthermore, within the liver, the maturation of the lipogenic transcription factor sterol regulatory element-binding protein-1c was increased in FGF21KO mice, implicating posttranscriptional events in the maladaptation of FGF21KO mice to KD. These data reinforce the role of FGF21 is a critical regulator of long-term energy balance and metabolism. Mice lacking FGF21 cannot respond appropriately to a ketogenic diet, resulting in an impaired ability to mobilize and utilize lipids." @default.
• W2020958481 created "2016-06-24" @default.
• W2020958481 creator A5014440856 @default.
• W2020958481 creator A5017534508 @default.
• W2020958481 creator A5051918182 @default.
• W2020958481 creator A5068454785 @default.
• W2020958481 creator A5071232361 @default.
• W2020958481 date "2009-10-09" @default.
• W2020958481 modified "2023-10-11" @default.
• W2020958481 title "Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis" @default.
• W2020958481 cites W1970761589 @default.
• W2020958481 cites W1989584881 @default.
• W2020958481 cites W1992864925 @default.
• W2020958481 cites W1996069144 @default.
• W2020958481 cites W2000665430 @default.
• W2020958481 cites W2006024610 @default.
• W2020958481 cites W2031514101 @default.
• W2020958481 cites W2048411348 @default.
• W2020958481 cites W2064120191 @default.
• W2020958481 cites W2079132151 @default.
• W2020958481 cites W2110534048 @default.
• W2020958481 cites W2111653877 @default.
• W2020958481 cites W2114650931 @default.
• W2020958481 cites W2119331212 @default.
• W2020958481 cites W2119351413 @default.
• W2020958481 cites W2121049950 @default.
• W2020958481 cites W2121330405 @default.
• W2020958481 cites W2124711253 @default.
• W2020958481 cites W2130700195 @default.
• W2020958481 cites W2131085646 @default.
• W2020958481 cites W2131622156 @default.
• W2020958481 cites W2134810803 @default.
• W2020958481 cites W2147029239 @default.
• W2020958481 cites W2150767656 @default.
• W2020958481 cites W2155010729 @default.
• W2020958481 cites W2166979654 @default.
• W2020958481 cites W2168050451 @default.
• W2020958481 doi "https://doi.org/10.1210/en.2009-0532" @default.
• W2020958481 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2775979" @default.
• W2020958481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19819944" @default.
• W2020958481 hasPublicationYear "2009" @default.
• W2020958481 type Work @default.
• W2020958481 sameAs 2020958481 @default.
• W2020958481 citedByCount "308" @default.
• W2020958481 countsByYear W20209584812012 @default.
• W2020958481 countsByYear W20209584812013 @default.
• W2020958481 countsByYear W20209584812014 @default.
• W2020958481 countsByYear W20209584812015 @default.
• W2020958481 countsByYear W20209584812016 @default.
• W2020958481 countsByYear W20209584812017 @default.
• W2020958481 countsByYear W20209584812018 @default.
• W2020958481 countsByYear W20209584812019 @default.
• W2020958481 countsByYear W20209584812020 @default.
• W2020958481 countsByYear W20209584812021 @default.
• W2020958481 countsByYear W20209584812022 @default.
• W2020958481 countsByYear W20209584812023 @default.
• W2020958481 crossrefType "journal-article" @default.
• W2020958481 hasAuthorship W2020958481A5014440856 @default.
• W2020958481 hasAuthorship W2020958481A5017534508 @default.
• W2020958481 hasAuthorship W2020958481A5051918182 @default.
• W2020958481 hasAuthorship W2020958481A5068454785 @default.
• W2020958481 hasAuthorship W2020958481A5071232361 @default.
• W2020958481 hasBestOaLocation W20209584812 @default.
• W2020958481 hasConcept C104317684 @default.
• W2020958481 hasConcept C106646824 @default.
• W2020958481 hasConcept C126322002 @default.
• W2020958481 hasConcept C134018914 @default.
• W2020958481 hasConcept C138463869 @default.
• W2020958481 hasConcept C170493617 @default.
• W2020958481 hasConcept C171089720 @default.
• W2020958481 hasConcept C2491326 @default.
• W2020958481 hasConcept C2775936931 @default.
• W2020958481 hasConcept C2776731943 @default.
• W2020958481 hasConcept C2777391703 @default.
• W2020958481 hasConcept C2779306644 @default.
• W2020958481 hasConcept C2780606744 @default.
• W2020958481 hasConcept C2780642333 @default.
• W2020958481 hasConcept C3018667095 @default.
• W2020958481 hasConcept C31532488 @default.
• W2020958481 hasConcept C511355011 @default.
• W2020958481 hasConcept C55493867 @default.
• W2020958481 hasConcept C555293320 @default.
• W2020958481 hasConcept C62231903 @default.
• W2020958481 hasConcept C6929976 @default.
• W2020958481 hasConcept C71924100 @default.
• W2020958481 hasConcept C74373430 @default.
• W2020958481 hasConcept C84693403 @default.
• W2020958481 hasConcept C86803240 @default.
• W2020958481 hasConceptScore W2020958481C104317684 @default.
• W2020958481 hasConceptScore W2020958481C106646824 @default.
• W2020958481 hasConceptScore W2020958481C126322002 @default.
• W2020958481 hasConceptScore W2020958481C134018914 @default.
• W2020958481 hasConceptScore W2020958481C138463869 @default.
• W2020958481 hasConceptScore W2020958481C170493617 @default.
• W2020958481 hasConceptScore W2020958481C171089720 @default.
• W2020958481 hasConceptScore W2020958481C2491326 @default.
• W2020958481 hasConceptScore W2020958481C2775936931 @default.
• W2020958481 hasConceptScore W2020958481C2776731943 @default.

• next