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• W2020963721 startingPage "603" @default.
• W2020963721 abstract "Rats suppress intake of a saccharin conditioned stimulus (CS) when paired with an aversive unconditioned stimulus such as lithium chloride. This phenomenon is referred to as a conditioned taste aversion (CTA). Rats also suppress intake of a saccharin CS when paired with a rewarding sucrose solution and when paired with a drug of abuse. Although the suppressive effects of drugs of abuse have long been interpreted as CTAs, evidence suggests that rats may suppress intake of the saccharin CS following taste–drug pairings because they are anticipating the rewarding rather than the aversive properties of the drug. Oddly, however, while all other drugs of abuse tested suppress intake of a gustatory CS, the highly reinforcing drug, heroin, is reportedly ineffective. The present study reexamined this issue in both water-deprived and water-replete rats using procedures that sustain both morphine- and cocaine-induced suppression of CS intake. The results showed that heroin greatly reduced CS intake following saccharin-heroin pairings and that this effect was less variable when assessed in water-replete subjects. When taken with other reports, these data suggest that rats suppress intake of a saccharin CS in anticipation of the availability of all drugs of abuse tested." @default.
• W2020963721 created "2016-06-24" @default.
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• W2020963721 creator A5020432691 @default.
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• W2020963721 date "2000-07-01" @default.
• W2020963721 modified "2023-10-16" @default.
• W2020963721 title "Heroin-induced Suppression of Saccharin Intake in Water-Deprived and Water-Replete Rats" @default.
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• W2020963721 doi "https://doi.org/10.1016/s0091-3057(00)00253-7" @default.
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