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• W2020970462 startingPage "77" @default.
• W2020970462 abstract "Oridonin has been traditionally and widely used for treatment of various human diseases due to its uniquely biological, pharmacological and physiological functions. In this study, the interaction between oridonin and human serum albumin (HSA) was investigated using isothermal titration calorimetry (ITC), in combination with fluorescence spectroscopy and UV–vis absorption spectroscopy. We found that the hydrogen bond and van der Waals force are the major binding forces in the binding of oridonin to HSA. The binding of oridonin to HSA is driven by favorable enthalpy and unfavorable entropy. Oridonin can quench the fluorescence of HSA through a static quenching mechanism. The binding constant between oridonin and HSA is moderate and the equilibrium fraction of unbound oridonin fu > 60%. Binding site I is found to be the primary binding site for oridonin. Additionally, oridonin may induce conformational changes of HSA and affect its biological function as the carrier protein. The results of the current study suggest that oridonin can be stored and transported from the circulatory system to reach its target organ to provide its therapeutic effects. But its side-effect in the clinics cannot be overlook. The study provides an accurate and full basic data for clarifying the binding mechanism of oridonin with HSA and is helpful for understanding its effect on protein function during the blood transportation process and its biological activity in vivo." @default.
• W2020970462 created "2016-06-24" @default.
• W2020970462 creator A5021138691 @default.
• W2020970462 creator A5078511514 @default.
• W2020970462 date "2015-05-01" @default.
• W2020970462 modified "2023-09-27" @default.
• W2020970462 title "Interaction of oridonin with human serum albumin by isothermal titration calorimetry and spectroscopic techniques" @default.
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• W2020970462 doi "https://doi.org/10.1016/j.cbi.2015.03.012" @default.
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