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• W2020973399 abstract "RNA editing provides a post-transcriptional mechanism to increase structural heterogeneity of gene products. Recently, the α3 subunit of the GABA A receptors has been shown to undergo RNA editing. As a result, a highly conserved isoleucine residue in the third transmembrane domain is replaced with a methionine . To determine the effect of this structural change on receptor function, we compared the GABA sensitivity, pharmacological properties and macroscopic kinetics of recombinant receptors containing either the edited or unedited forms of the α3 subunit along with β3 and γ2L. Editing substantially altered the GABA sensitivity and deactivation rate of the receptors, with the unedited form showing a lower GABA EC 50 and slower decay. Comparable effects were observed with a mutation at the homologous location in the α1 subunit, suggesting a common role for this site in regulation of channel gating. Except for the response to GABA, the pharmacological properties of the receptor were unaffected by editing, with similar enhancement by a variety of modulators. Since RNA editing of the α3 subunit increases through development, our findings suggest that GABAergic neurotransmission may be more effective early in development, with greater GABA sensitivity and slower decay rates conferred by the unedited α3 subunit." @default.
• W2020973399 created "2016-06-24" @default.
• W2020973399 creator A5033409068 @default.
• W2020973399 creator A5056588220 @default.
• W2020973399 creator A5062901554 @default.
• W2020973399 date "2009-04-01" @default.
• W2020973399 modified "2023-09-24" @default.
• W2020973399 title "RNA editing of the GABAA receptor α3 subunit alters the functional properties of recombinant receptors" @default.
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• W2020973399 doi "https://doi.org/10.1016/j.neures.2009.01.003" @default.
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