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• W2020977090 abstract "In this study we investigated the effect of pre-treatment with 3-alkynyl selenophene (3-ASP) against the increase in responsiveness to pentylenetetrazole [PTZ seizure threshold] and cognitive dysfunction induced by experimental febrile seizures (FS). The effects of 3-ASP were compared to those of diazepam (DZP). Young rats, at postnatal day 21, developed seizures after exposure to a stream of heated air to approximately 41 °C. A non-spatial long-term memory and PTZ seizure threshold were determined 30 days after FS. The behavioural seizures were stereotyped followed by facial automatisms, often followed by body flexion. Young rats were pre-treated with 3-ASP (50 and 100 mg/kg; per oral route), DZP (1 and 5 mg/kg; intraperitoneally) or vehicle. 3-ASP and DZP pre-treatments were not effective in protecting against seizures induced by FS. 3-ASP pre-treatment protected against the increase in responsiveness to PTZ and cognitive dysfunction induced by FS. DZP pre-treatment was effective in protecting against the increase in responsiveness to PTZ, but not, against the impaired memory induced by FS. 3-ASP pre-treatment protected against impairment of memory performance in the step-down passive avoidance task and the increase in the susceptibility to seizures caused by FS early in life of rats." @default.
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• W2020977090 date "2012-05-01" @default.
• W2020977090 modified "2023-09-26" @default.
• W2020977090 title "Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: Protective effect of 3-alkynyl selenophene" @default.
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• W2020977090 doi "https://doi.org/10.1016/j.lfs.2012.03.005" @default.
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