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• W2020989723 abstract "In natural environments, heterotrophic microorganisms encounter complex mixtures of carbon sources, each of which is present only at very low concentrations. Under such conditions no significant growth could be expected if cells utilized only one of the available carbon compounds as suggested by the principle of diauxic growth. Indeed, there is much evidence that microbial cells utilize many carbon sources simultaneously. In order to predict bacterial growth under such conditions we developed a model describing the specific growth rate as a function of the individual concentrations of several simultaneously utilized carbon substrates. Together with multisubstrate models previously published, this model was evaluated for its ability to describe growth of Escherichia coli during the simultaneous utilization of mixtures of sugars in carbon-limited continuous culture. Using the μmax and Ks constants determined for single substrate growth with six different sugars, the model was able for most experiments to adequately describe the specific growth rate of the culture, i.e., the experimentally set dilution rate, from the measured concentrations of the individual sugars. The model provides an explanation why bacteria can still grow relatively fast under environmental conditions where the concentrations of carbon substrates are usually extremely low. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 59:99–107, 1998." @default.
• W2020989723 created "2016-06-24" @default.
• W2020989723 creator A5078248367 @default.
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• W2020989723 date "1998-07-05" @default.
• W2020989723 modified "2023-10-01" @default.
• W2020989723 title "Kinetic models for the growth ofEscherichia coli with mixtures of sugars under carbon-limited conditions" @default.
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• W2020989723 doi "https://doi.org/10.1002/(sici)1097-0290(19980705)59:1<99::aid-bit13>3.0.co;2-y" @default.
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