FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020993332> ?p ?o ?g. }

• W2020993332 endingPage "4808" @default.
• W2020993332 startingPage "4804" @default.
• W2020993332 abstract "Expression of the retinoic acid receptors alpha and beta (RAR-alpha and RAR-beta) was examined in F9 cells, an embryonal carcinoma cell model established for the study of retinoid metabolism and function. Addition of retinoic acid to F9 cell medium caused a dose-dependent increase in RAR-beta mRNA within 3 hr that reached 5- to 30-fold greater than the constitutively expressed mRNA by 24 hr. The elevation in mRNA resulted from increased transcription, as demonstrated by nuclear run-on transcription, did not require protein synthesis, and required the constant presence of retinoic acid. N6,O2'-Dibutyryl-cAMP attenuated the retinoic acid-induced increase in RAR-beta mRNA by a post-transcriptional mechanism. In contrast, RAR-alpha mRNA in F9 stem cells was affected less (1.2- to 1.4-fold increase) by retinoic acid and decreased 3-fold transiently when fresh serum was added to the medium. Differentiation of F9 cells resulted in increased steady-state levels of RAR-beta mRNA in primitive (4-fold), parietal (3-fold), and visceral (8-fold) endoderm but decreased steady-state levels of RAR-alpha mRNA in primitive (2-fold), parietal (3-fold), and visceral (1.4-fold) endoderm. These data demonstrate that RAR-beta is a primary target gene for retinoic acid in a characterized model of retinoid function, indicate that constitutive expression of both RAR-beta and RAR-alpha is dependent upon the differentiation state, and suggest hormonal modulation of RAR-beta by cAMP and modulation of RAR-alpha by serum factors. These results distinguish the effects of serum, cAMP, and retinoic acid on the expression of RAR from the effects mediated by differentiation." @default.
• W2020993332 created "2016-06-24" @default.
• W2020993332 creator A5061423928 @default.
• W2020993332 creator A5076606477 @default.
• W2020993332 creator A5086997418 @default.
• W2020993332 date "1990-06-01" @default.
• W2020993332 modified "2023-09-26" @default.
• W2020993332 title "Retinoic acid, dibutyryl-cAMP, and differentiation affect the expression of retinoic acid receptors in F9 cells." @default.
• W2020993332 cites W1492098854 @default.
• W2020993332 cites W1493100105 @default.
• W2020993332 cites W1586300778 @default.
• W2020993332 cites W1603968791 @default.
• W2020993332 cites W1674312737 @default.
• W2020993332 cites W1796722199 @default.
• W2020993332 cites W180170051 @default.
• W2020993332 cites W1970470854 @default.
• W2020993332 cites W1973007853 @default.
• W2020993332 cites W2003932465 @default.
• W2020993332 cites W2005116045 @default.
• W2020993332 cites W2020555116 @default.
• W2020993332 cites W2030488757 @default.
• W2020993332 cites W2042925243 @default.
• W2020993332 cites W2049791242 @default.
• W2020993332 cites W2051663421 @default.
• W2020993332 cites W2052848609 @default.
• W2020993332 cites W2053520712 @default.
• W2020993332 cites W2060333964 @default.
• W2020993332 cites W2061178138 @default.
• W2020993332 cites W2068431302 @default.
• W2020993332 cites W2070547356 @default.
• W2020993332 cites W2071415208 @default.
• W2020993332 cites W2072233737 @default.
• W2020993332 cites W2075788654 @default.
• W2020993332 cites W2079514647 @default.
• W2020993332 cites W2085124463 @default.
• W2020993332 cites W2085565355 @default.
• W2020993332 cites W2090931042 @default.
• W2020993332 cites W2102420525 @default.
• W2020993332 cites W2264931750 @default.
• W2020993332 doi "https://doi.org/10.1073/pnas.87.12.4804" @default.
• W2020993332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/54206" @default.
• W2020993332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2162058" @default.
• W2020993332 hasPublicationYear "1990" @default.
• W2020993332 type Work @default.
• W2020993332 sameAs 2020993332 @default.
• W2020993332 citedByCount "74" @default.
• W2020993332 countsByYear W20209933322013 @default.
• W2020993332 countsByYear W20209933322018 @default.
• W2020993332 countsByYear W20209933322019 @default.
• W2020993332 countsByYear W20209933322021 @default.
• W2020993332 countsByYear W20209933322022 @default.
• W2020993332 crossrefType "journal-article" @default.
• W2020993332 hasAuthorship W2020993332A5061423928 @default.
• W2020993332 hasAuthorship W2020993332A5076606477 @default.
• W2020993332 hasAuthorship W2020993332A5086997418 @default.
• W2020993332 hasBestOaLocation W20209933321 @default.
• W2020993332 hasConcept C104317684 @default.
• W2020993332 hasConcept C105580179 @default.
• W2020993332 hasConcept C119775778 @default.
• W2020993332 hasConcept C120197328 @default.
• W2020993332 hasConcept C126322002 @default.
• W2020993332 hasConcept C134018914 @default.
• W2020993332 hasConcept C148738053 @default.
• W2020993332 hasConcept C153911025 @default.
• W2020993332 hasConcept C170493617 @default.
• W2020993332 hasConcept C19431177 @default.
• W2020993332 hasConcept C2775954498 @default.
• W2020993332 hasConcept C2779963572 @default.
• W2020993332 hasConcept C2781121885 @default.
• W2020993332 hasConcept C54355233 @default.
• W2020993332 hasConcept C55493867 @default.
• W2020993332 hasConcept C71924100 @default.
• W2020993332 hasConcept C81885089 @default.
• W2020993332 hasConcept C86803240 @default.
• W2020993332 hasConceptScore W2020993332C104317684 @default.
• W2020993332 hasConceptScore W2020993332C105580179 @default.
• W2020993332 hasConceptScore W2020993332C119775778 @default.
• W2020993332 hasConceptScore W2020993332C120197328 @default.
• W2020993332 hasConceptScore W2020993332C126322002 @default.
• W2020993332 hasConceptScore W2020993332C134018914 @default.
• W2020993332 hasConceptScore W2020993332C148738053 @default.
• W2020993332 hasConceptScore W2020993332C153911025 @default.
• W2020993332 hasConceptScore W2020993332C170493617 @default.
• W2020993332 hasConceptScore W2020993332C19431177 @default.
• W2020993332 hasConceptScore W2020993332C2775954498 @default.
• W2020993332 hasConceptScore W2020993332C2779963572 @default.
• W2020993332 hasConceptScore W2020993332C2781121885 @default.
• W2020993332 hasConceptScore W2020993332C54355233 @default.
• W2020993332 hasConceptScore W2020993332C55493867 @default.
• W2020993332 hasConceptScore W2020993332C71924100 @default.
• W2020993332 hasConceptScore W2020993332C81885089 @default.
• W2020993332 hasConceptScore W2020993332C86803240 @default.
• W2020993332 hasIssue "12" @default.
• W2020993332 hasLocation W20209933321 @default.
• W2020993332 hasLocation W20209933322 @default.
• W2020993332 hasLocation W20209933323 @default.
• W2020993332 hasLocation W20209933324 @default.
• W2020993332 hasOpenAccess W2020993332 @default.

• next