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- W2020994191 abstract "To the Editor: The rate of gastric emptying (GE) may effect the absorption of digoxin, penicillin and other drugs of importance to the pulmonologist1Nimmo W.S. Drugs, disease and altered gastric emptying.Clin Pharmacology. 1976; 1: 189-203Crossref Scopus (165) Google Scholar Aware that nicotine gum (NG) is often used in smoking cessation therapy,2Henningfield F.E. Nemeth-Coslette R. Nicotine dependence. Interface between tobacco and tobacco-related disease.Chest. 1988; 2: 37-55Crossref Google Scholar we looked at its effect upon GE. We measured GE times (GET1/2) using a Tc-99m-sulfur colloid-labelled meal3Chaudhuri T.K. Fink S. Lack of effect of indomethocin on gastric emptying in old men.J Am Ger Soc. 1984; 32: 19-20Crossref Scopus (2) Google Scholar in ten habitual cigarette smokers (38 to 76 years of age, mean 56 years) free of significant gastrointestinal history or recent complaints. Subjects fasted and refrained from smoking for eight to ten hours, then chewed gum containing 2 mg of nicotine (N) during one test and an identical gum devoid of N in the other. All were aware of a local sensation while chewing the NG, but no tests were interrupted because of these effects. The difference in emptying times between NG and placebo gum was not statistically significant. There was no correlation between GE rate with NG and high vs low N cigarette use or pack-year history. We believe that this pilot study confirms the safety of using NG therapeutically, even in patients who are coincidentally taking medication which could be affected by significantly altered gastric motility." @default.
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- W2020994191 date "1988-11-01" @default.
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- W2020994191 title "Effect of Nicotine Gum on Gastric Emptying" @default.
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- W2020994191 doi "https://doi.org/10.1378/chest.94.5.1122a" @default.
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