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- W2020996888 abstract "Abstract Progesterone facilitates extinction of a pole-jumping avoidance response after sc administration of 0.2 mg and 1.0 mg in a dose-dependent manner. A similar effect was found after intracerebral administration in the mesencephalic-diencephalic structures at the posterior thalamic level. However, systemic administration of 1.0 mg of this steroid did not alter escape speed of rats in a runway, and up to 10 mg did not affect ambulation and had only weak effects on rearing and defecation in an open field. Hydroxydione, a steroid with a much higher anesthetic activity than progesterone, appeared to be ineffective in facilitating avoidance extinction after sc administration of the same amounts in which progesterone caused facilitation of avoidance extinction. It did not alter escape speed in the runway but a dose of 10 mg reduced ambulation in an open field, without affecting rearing, grooming, and defecation. These results indicate, that the effect of progesterone on avoidance behavior is not due to anesthetic properties nor to a general depressive action." @default.
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- W2020996888 title "Analysis of the effect of progesterone on avoidance behavior" @default.
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