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- W2021000732 abstract "2263 Prior exercise can lead to a subsequent increase in insulin-stimulated glucose transport (GT) in skeletal muscle of rats and humans of either gender, but little is known about the effect of prior exercise on insulin-stimulated GT in mice, regardless of gender. Because mice are commonly used for transgenic studies, understanding the effects of exercise in this species is important. PURPOSE: The goal of this study was to characterize the effects of prior swimming exercise on subsequent insulin-stimulated GT in isolated muscles (soleus and extensor digitorum longus, EDL) of female and male mice. METHODS: Male and female mice performed 3 hours of swim exercise (6 × 30 minutes, with 5 minutes rest between bouts) or were sedentary controls. At approximately 20, 80, or 200 minutes post-exercise, soleus and EDL muscles were dissected out of anesthetized mice and incubated for 30 min before GT was determined using radiolabeled 2-deoxyglucose. GT was determined without insulin for one soleus and EDL from each mouse, and the contralateral muscles were used to measure GT with a physiologic insulin concentration (30 uU/ml). Two Way ANOVA (Gender × Exercise) with Tukey post-hoc test was used to analyze GT without insulin and with insulin. RESULTS: GT was higher for females than males without insulin (soleus, p=0.033; EDL, p=0.001) and with insulin (soleus, p=0.019; EDL, p=0.012). For insulin-treated EDL, there was a significant Exercise effect (p=0.023), such that the 20 minutes post-exercise values exceeded the values for the sedentary group and the 200 minutes post-exercise group. There was a significant Gender × Exercise interaction (p=0.011) for GT in the EDL without insulin, and post-hoc analysis revealed that the 20min post-exercise value for males was significantly greater than all other male groups (sedentary, 80min post-exercise, and 200min post-exercise). CONCLUSION: Soleus and EDL GT values were consistently higher for females vs. males. The exercise effect was transient (only at 20 minutes post-exercise), muscle-specific (in EDL but not soleus), and gender-dependent (only in males without insulin). These results will be useful for designing future studies aimed at elucidating mechanisms underlying the effects of exercise on GT. Supported by Virginia Horne Henry Fund for Women's Physical Education" @default.
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- W2021000732 date "2004-05-01" @default.
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- W2021000732 title "Effects of Gender and Prior Exercise on Glucose Transport in Isolated Skeletal Muscle from Mice" @default.
- W2021000732 doi "https://doi.org/10.1097/00005768-200405001-01567" @default.
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