Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021000934> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2021000934 endingPage "556" @default.
- W2021000934 startingPage "553" @default.
- W2021000934 abstract "The serine protease inhibitor antithrombin-III (AT-III) is the principal in vivo inhibitor of blood coagulation, inactivating mainly thrombin, but also other serine proteases. Binding of AT-III to heparin dramatically increases its inhibitory effect. AT-III deficiency during cardiopulmonary bypass (CPB) can lead to insufficient anticoagulation which cannot be treated by higher doses of heparin. A 60-year-old male with familial AT-III deficiency was admitted to our hospital for coronary artery bypass surgery and aortic valve replacement. Four days before the operation, acenocoumarol was stopped and anti-X a nadroparincalcium (Fraxiparine) was started. AT-III activity at that time was 56%. Two hours before the operation, a single dose of 4500 IU AT-III concentrate was administered. Heparinization was performed with 400 IU/kg of porcine mucosal heparin, increasing the activated coagulation time (ACT) from a baseline of 115 to 549 s. AT-III activity at that time was above 100% and the plasma D-dimer concentration was 230 ng/l. ACTs during CPB remained above 999 s, whereas the AT-III activity dropped to 54% and the D-dimer increased up to 500 ng/l at the end of CPB. CPB was terminated uneventfully. Heparin was reversed with 3 mg/kg protamine chloride, decreasing the ACT to 155 s. In the intensive care unit (ICU), the patient received prophylactic Fraxiparine and 1500 IU AT-III, increasing the AT-III activity to 84%. Postoperatively, there was continued blood loss, which necessitated the administration of whole blood and eventually re-exploration. The case presented illustrates an uneventful treatment of a patient with a hereditary AT-III deficiency undergoing CPB. In spite of an uneventful treatment with AT-III pre-CPB, administration of prophylactic AT-III concentrate after surgery should be considered with caution, as this might increase the postoperative morbidity." @default.
- W2021000934 created "2016-06-24" @default.
- W2021000934 creator A5020328909 @default.
- W2021000934 creator A5053548003 @default.
- W2021000934 creator A5064557399 @default.
- W2021000934 creator A5085688118 @default.
- W2021000934 creator A5086328509 @default.
- W2021000934 date "2000-12-01" @default.
- W2021000934 modified "2023-10-14" @default.
- W2021000934 title "Familial antithrombin-III deficiency during cardiopulmonary bypass: a case report" @default.
- W2021000934 cites W1992566097 @default.
- W2021000934 cites W2020694202 @default.
- W2021000934 cites W2047745161 @default.
- W2021000934 cites W2056936950 @default.
- W2021000934 cites W2326494422 @default.
- W2021000934 cites W307559345 @default.
- W2021000934 cites W4323284267 @default.
- W2021000934 doi "https://doi.org/10.1177/026765910001500613" @default.
- W2021000934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11131221" @default.
- W2021000934 hasPublicationYear "2000" @default.
- W2021000934 type Work @default.
- W2021000934 sameAs 2021000934 @default.
- W2021000934 citedByCount "6" @default.
- W2021000934 countsByYear W20210009342013 @default.
- W2021000934 countsByYear W20210009342016 @default.
- W2021000934 countsByYear W20210009342020 @default.
- W2021000934 crossrefType "journal-article" @default.
- W2021000934 hasAuthorship W2021000934A5020328909 @default.
- W2021000934 hasAuthorship W2021000934A5053548003 @default.
- W2021000934 hasAuthorship W2021000934A5064557399 @default.
- W2021000934 hasAuthorship W2021000934A5085688118 @default.
- W2021000934 hasAuthorship W2021000934A5086328509 @default.
- W2021000934 hasConcept C126322002 @default.
- W2021000934 hasConcept C141071460 @default.
- W2021000934 hasConcept C152328610 @default.
- W2021000934 hasConcept C181199279 @default.
- W2021000934 hasConcept C185592680 @default.
- W2021000934 hasConcept C2777557582 @default.
- W2021000934 hasConcept C2777987278 @default.
- W2021000934 hasConcept C2778382381 @default.
- W2021000934 hasConcept C2778881276 @default.
- W2021000934 hasConcept C2779026020 @default.
- W2021000934 hasConcept C2780799893 @default.
- W2021000934 hasConcept C2780835560 @default.
- W2021000934 hasConcept C2994232697 @default.
- W2021000934 hasConcept C42219234 @default.
- W2021000934 hasConcept C52853521 @default.
- W2021000934 hasConcept C55493867 @default.
- W2021000934 hasConcept C71924100 @default.
- W2021000934 hasConceptScore W2021000934C126322002 @default.
- W2021000934 hasConceptScore W2021000934C141071460 @default.
- W2021000934 hasConceptScore W2021000934C152328610 @default.
- W2021000934 hasConceptScore W2021000934C181199279 @default.
- W2021000934 hasConceptScore W2021000934C185592680 @default.
- W2021000934 hasConceptScore W2021000934C2777557582 @default.
- W2021000934 hasConceptScore W2021000934C2777987278 @default.
- W2021000934 hasConceptScore W2021000934C2778382381 @default.
- W2021000934 hasConceptScore W2021000934C2778881276 @default.
- W2021000934 hasConceptScore W2021000934C2779026020 @default.
- W2021000934 hasConceptScore W2021000934C2780799893 @default.
- W2021000934 hasConceptScore W2021000934C2780835560 @default.
- W2021000934 hasConceptScore W2021000934C2994232697 @default.
- W2021000934 hasConceptScore W2021000934C42219234 @default.
- W2021000934 hasConceptScore W2021000934C52853521 @default.
- W2021000934 hasConceptScore W2021000934C55493867 @default.
- W2021000934 hasConceptScore W2021000934C71924100 @default.
- W2021000934 hasIssue "6" @default.
- W2021000934 hasLocation W20210009341 @default.
- W2021000934 hasLocation W20210009342 @default.
- W2021000934 hasOpenAccess W2021000934 @default.
- W2021000934 hasPrimaryLocation W20210009341 @default.
- W2021000934 hasRelatedWork W1986745236 @default.
- W2021000934 hasRelatedWork W2004641063 @default.
- W2021000934 hasRelatedWork W2021000934 @default.
- W2021000934 hasRelatedWork W2033247272 @default.
- W2021000934 hasRelatedWork W2038446001 @default.
- W2021000934 hasRelatedWork W2410629063 @default.
- W2021000934 hasRelatedWork W2414219585 @default.
- W2021000934 hasRelatedWork W2414531805 @default.
- W2021000934 hasRelatedWork W2049455104 @default.
- W2021000934 hasRelatedWork W2463044835 @default.
- W2021000934 hasVolume "15" @default.
- W2021000934 isParatext "false" @default.
- W2021000934 isRetracted "false" @default.
- W2021000934 magId "2021000934" @default.
- W2021000934 workType "article" @default.