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- W2021001073 abstract "A diet containing 0.05 % of 2-acetylaminofluorene (2-AAF) was administered to male rats of the Leeds strain. Animals were killed after 7–10 days, 3–4 weeks and 8–12 weeks of carcinogen treatment and their hepatic tissue was examined by electron microscopy. 2-AAF appeared to differ, in its effect on the fine structure of the hepatocyte, from many other hepatocarcinogens in failing to produce visible nuclear changes. The changes produced by 2-AAF included glycogen depletion, proliferation of the agranular endoplasmic reticulum, reduction in the quantity and morphological alterations of the granular endoplasmic reticulum, progressive hypertrophy of the Golgi apparatus with an associated increase in lysosomal abundance and, during the later stages of treatment, a reduction in mitochondrial size. Changes affecting the plasma membrane were also observed, including dilatation of the bile canaliculi. Some of the observed changes appear to be related to those previously observed in preneoplastic liver cells and hepatoma cells of 2-AAF-treated rats and may, therefore, be related to the carcinogenic activity of 2-AAF." @default.
- W2021001073 created "2016-06-24" @default.
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- W2021001073 date "1970-08-01" @default.
- W2021001073 modified "2023-09-24" @default.
- W2021001073 title "Changes in the fine structure of rat hepatocytes during the early phases of chronic 2-acetylaminofluorene intoxication" @default.
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- W2021001073 doi "https://doi.org/10.1016/0009-2797(70)90045-1" @default.
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