Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021001433> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2021001433 endingPage "2039" @default.
- W2021001433 startingPage "2033" @default.
- W2021001433 abstract "The present investigation was designed to determine whether atrial natriuretic peptides consisting of amino acids 1-30 (i.e. long-acting natriuretic peptide), 31-67 (vessel dilator), 79-98 (kaliuretic peptide), and 99-126 [atrial natriuretic factor (ANF)] of the 126 amino acid ANF prohormone inhibit sodium-potassium-ATPase as part of their mechanism(s) of action for producing a natriuresis and/or kaliuresis. Kaliuretic peptide, long-acting natriuretic peptide, vessel dilator and ANF at their 10(-11) M concentrations inhibited Na(+)-K(+)-ATPase 39.5%, 27.8%, 19.2%, and 4% respectively, in bovine renal medulla, whereas their inhibition in renal cortical membranes was 37.5%, 27.5%, 20%, and 0%, respectively. Ouabain (0.5 mM) inhibited kidney medullary Na(+)-K(+)-ATPase 45% and in the cortex, 38%. There was no additive effect of any of these peptides with ouabain suggesting that they are interacting with the same site on the Na(+)-K(+)-ATPase as ouabain. To help elucidate the mechanism of these peptides' interaction with Na(+)-K(+)-ATPase, naproxen (0.5 mM), an inhibitor of prostaglandin synthesis, and direct measurement of prostaglandin E2 by RIA were used. Naproxen completely blocked the inhibition of Na(+)-K(+)-ATPase by kaliuretic peptide, long-acting natriuretic peptide, and vessel dilator suggesting that their inhibition of Na(+)-K(+)-ATPase in both the kidney medulla and cortex are mediated by prostaglandins. Direct measurement of prostaglandin E2 revealed that kaliuretic peptide > long-acting natriuretic peptide > vessel dilator increased prostaglandin E2 synthesis, whereas ANF did not have any effect. Of interest, angiotensin II and ouabain inhibition of Na(+)-K(+)-ATPase were also completely blocked by naproxen." @default.
- W2021001433 created "2016-06-24" @default.
- W2021001433 creator A5008625442 @default.
- W2021001433 creator A5021856429 @default.
- W2021001433 date "1995-05-01" @default.
- W2021001433 modified "2023-10-16" @default.
- W2021001433 title "Kaliuretic peptide: the most potent inhibitor of Na(+)-K+ ATPase of the atrial natriuretic peptides." @default.
- W2021001433 doi "https://doi.org/10.1210/endo.136.5.7720651" @default.
- W2021001433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7720651" @default.
- W2021001433 hasPublicationYear "1995" @default.
- W2021001433 type Work @default.
- W2021001433 sameAs 2021001433 @default.
- W2021001433 citedByCount "35" @default.
- W2021001433 countsByYear W20210014332013 @default.
- W2021001433 countsByYear W20210014332014 @default.
- W2021001433 countsByYear W20210014332020 @default.
- W2021001433 countsByYear W20210014332023 @default.
- W2021001433 crossrefType "journal-article" @default.
- W2021001433 hasAuthorship W2021001433A5008625442 @default.
- W2021001433 hasAuthorship W2021001433A5021856429 @default.
- W2021001433 hasConcept C126322002 @default.
- W2021001433 hasConcept C134018914 @default.
- W2021001433 hasConcept C174459258 @default.
- W2021001433 hasConcept C178790620 @default.
- W2021001433 hasConcept C185592680 @default.
- W2021001433 hasConcept C2775915353 @default.
- W2021001433 hasConcept C2778069365 @default.
- W2021001433 hasConcept C2778198053 @default.
- W2021001433 hasConcept C2779133857 @default.
- W2021001433 hasConcept C2779281246 @default.
- W2021001433 hasConcept C2780011235 @default.
- W2021001433 hasConcept C2780091579 @default.
- W2021001433 hasConcept C537181965 @default.
- W2021001433 hasConcept C55493867 @default.
- W2021001433 hasConcept C71924100 @default.
- W2021001433 hasConcept C86803240 @default.
- W2021001433 hasConceptScore W2021001433C126322002 @default.
- W2021001433 hasConceptScore W2021001433C134018914 @default.
- W2021001433 hasConceptScore W2021001433C174459258 @default.
- W2021001433 hasConceptScore W2021001433C178790620 @default.
- W2021001433 hasConceptScore W2021001433C185592680 @default.
- W2021001433 hasConceptScore W2021001433C2775915353 @default.
- W2021001433 hasConceptScore W2021001433C2778069365 @default.
- W2021001433 hasConceptScore W2021001433C2778198053 @default.
- W2021001433 hasConceptScore W2021001433C2779133857 @default.
- W2021001433 hasConceptScore W2021001433C2779281246 @default.
- W2021001433 hasConceptScore W2021001433C2780011235 @default.
- W2021001433 hasConceptScore W2021001433C2780091579 @default.
- W2021001433 hasConceptScore W2021001433C537181965 @default.
- W2021001433 hasConceptScore W2021001433C55493867 @default.
- W2021001433 hasConceptScore W2021001433C71924100 @default.
- W2021001433 hasConceptScore W2021001433C86803240 @default.
- W2021001433 hasIssue "5" @default.
- W2021001433 hasLocation W20210014331 @default.
- W2021001433 hasLocation W20210014332 @default.
- W2021001433 hasOpenAccess W2021001433 @default.
- W2021001433 hasPrimaryLocation W20210014331 @default.
- W2021001433 hasRelatedWork W1799770855 @default.
- W2021001433 hasRelatedWork W1970446704 @default.
- W2021001433 hasRelatedWork W1984995072 @default.
- W2021001433 hasRelatedWork W2002038679 @default.
- W2021001433 hasRelatedWork W2043879443 @default.
- W2021001433 hasRelatedWork W2048449846 @default.
- W2021001433 hasRelatedWork W2082860182 @default.
- W2021001433 hasRelatedWork W2098870266 @default.
- W2021001433 hasRelatedWork W2106860651 @default.
- W2021001433 hasRelatedWork W2186282964 @default.
- W2021001433 hasVolume "136" @default.
- W2021001433 isParatext "false" @default.
- W2021001433 isRetracted "false" @default.
- W2021001433 magId "2021001433" @default.
- W2021001433 workType "article" @default.