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• W2021001823 abstract "Context: Azadirachta indica A. Juss (Meliaceae), commonly called neem is a plant native to the Indian sub-continent. Neem oil extracted from the seeds of neem tree has shown promising medicinal properties.Objective: To investigate the possible anti-mutagenic activity of neem seed oil (NO) and its dimethylsulfoxide (DMSO) extract (NDE) on the mutagenicity induced by various direct acting and activation-dependant mutagens.Materials and methods: The possible anti-mutagenic activity of NO (100–10 000 µg/plate) and NDE (0.1–1000 µg/plate) as well as the mechanism of anti-mutagenic activity was studied in an in vitro Ames Salmonella/microsome assay.Results: NSO and NDE inhibited the mutagenic activity of methyl glyoxal (MG), in which case the extent of inhibition ranged from 65 to 77% and against 4-nitroquinoline-N-oxide (NQNO); it showed a 48–87% inhibition in the non-toxic doses. Similar response of NSO and NDE was seen against the activation-dependant mutagens aflatoxin B1 (AFB1, 48–88%), benzo(a)pyrene (B(a)P, 31–85%), cyclophosphamide (CP, 66–71%), 20-methylcholanthrane (20-MC, 37–83%) and acridine orange (AO, 39–72%) in the non-toxic doses. Mechanism-based studies indicated that NDE exhibits better anti-mutagenic activity in the pre- and simultaneous-treatment protocol against MG, suggesting that one or several active phytochemicals present in the extract covalently bind with the mutagen and prevent its interaction with the genome.Discussion and conclusion: These findings demonstrate that neem oil is capable of attenuating the mutagenic activity of various direct acting and activation-dependant mutagens." @default.
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• W2021001823 date "2013-09-02" @default.
• W2021001823 modified "2023-09-26" @default.
• W2021001823 title "Inhibitory effects of neem seed oil and its extract on various direct acting and activation-dependant mutagens-induced bacterial mutagenesis" @default.
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• W2021001823 doi "https://doi.org/10.3109/13880209.2013.801020" @default.
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