FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021002240> ?p ?o ?g. }

• W2021002240 endingPage "631" @default.
• W2021002240 startingPage "620" @default.
• W2021002240 abstract "α-Tocopherol has been shown to increase nitric oxide (NO)-dependent relaxation but the underlying mechanisms have not been fully characterized. The present study investigates the effect of α-tocopherol and its derivative trolox on the synthesis of NO in human umbilical vein endothelial cells. NO was assayed as citrulline (co-product of NO) and cGMP (product of the NO-activated soluble guanylate cyclase) on ionomycin stimulation of cells. Ionomycin induced citrulline and cGMP formation partially through phosphorylation of endothelial NO synthase (eNOS) at its serine residue 1177, which was mediated mainly by calmodulin-dependent kinase II. Preincubation of cells with α-tocopherol or trolox increased eNOS activity in a concentration-dependent manner without changing eNOS expression. The effect of the water-soluble trolox was due to chemical stabilization of the eNOS cofactor tetrahydrobiopterin. On the contrary, α-tocopherol, located mainly in cellular membranes, did not affect tetrahydrobiopterin but increased ionomycin-induced eNOS phosphorylation at serine 1177. The effects of α-tocopherol on citrulline and cGMP formation and eNOS phosphorylation were amplified by co-incubation with ascorbate, which is suggested to regenerate oxidized α-tocopherol and to act synergistically with α-tocopherol. Our data describe a new vasoprotective function of α-tocopherol that may contribute to the prevention of endothelial dysfunction in vivo." @default.
• W2021002240 created "2016-06-24" @default.
• W2021002240 creator A5002616158 @default.
• W2021002240 creator A5054471282 @default.
• W2021002240 creator A5064092710 @default.
• W2021002240 creator A5064434910 @default.
• W2021002240 creator A5066954535 @default.
• W2021002240 creator A5077615625 @default.
• W2021002240 date "2004-09-01" @default.
• W2021002240 modified "2023-09-27" @default.
• W2021002240 title "α-Tocopherol Amplifies Phosphorylation of Endothelial Nitric Oxide Synthase at Serine 1177 and its Short-Chain Derivative Trolox Stabilizes Tetrahydrobiopterin" @default.
• W2021002240 cites W1496789829 @default.
• W2021002240 cites W1523585998 @default.
• W2021002240 cites W1607892649 @default.
• W2021002240 cites W1678800844 @default.
• W2021002240 cites W1851010840 @default.
• W2021002240 cites W1869682857 @default.
• W2021002240 cites W1895485518 @default.
• W2021002240 cites W1940935006 @default.
• W2021002240 cites W1965287270 @default.
• W2021002240 cites W1979542742 @default.
• W2021002240 cites W1980265413 @default.
• W2021002240 cites W1994768696 @default.
• W2021002240 cites W1997362992 @default.
• W2021002240 cites W1999371223 @default.
• W2021002240 cites W2024185487 @default.
• W2021002240 cites W2030378671 @default.
• W2021002240 cites W2035190863 @default.
• W2021002240 cites W2037632643 @default.
• W2021002240 cites W2052814883 @default.
• W2021002240 cites W2054150424 @default.
• W2021002240 cites W2057295103 @default.
• W2021002240 cites W2059694609 @default.
• W2021002240 cites W2068820862 @default.
• W2021002240 cites W2074612559 @default.
• W2021002240 cites W2074858413 @default.
• W2021002240 cites W2087018994 @default.
• W2021002240 cites W2107947903 @default.
• W2021002240 cites W2113388598 @default.
• W2021002240 cites W2117894872 @default.
• W2021002240 cites W2121576674 @default.
• W2021002240 cites W2124844511 @default.
• W2021002240 cites W2127072099 @default.
• W2021002240 cites W2131058177 @default.
• W2021002240 cites W2135297555 @default.
• W2021002240 cites W2144179854 @default.
• W2021002240 cites W2167927369 @default.
• W2021002240 cites W2320793908 @default.
• W2021002240 cites W4241426451 @default.
• W2021002240 doi "https://doi.org/10.1016/j.freeradbiomed.2004.05.017" @default.
• W2021002240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15288120" @default.
• W2021002240 hasPublicationYear "2004" @default.
• W2021002240 type Work @default.
• W2021002240 sameAs 2021002240 @default.
• W2021002240 citedByCount "28" @default.
• W2021002240 countsByYear W20210022402012 @default.
• W2021002240 countsByYear W20210022402013 @default.
• W2021002240 countsByYear W20210022402014 @default.
• W2021002240 countsByYear W20210022402016 @default.
• W2021002240 countsByYear W20210022402018 @default.
• W2021002240 countsByYear W20210022402019 @default.
• W2021002240 countsByYear W20210022402020 @default.
• W2021002240 countsByYear W20210022402021 @default.
• W2021002240 crossrefType "journal-article" @default.
• W2021002240 hasAuthorship W2021002240A5002616158 @default.
• W2021002240 hasAuthorship W2021002240A5054471282 @default.
• W2021002240 hasAuthorship W2021002240A5064092710 @default.
• W2021002240 hasAuthorship W2021002240A5064434910 @default.
• W2021002240 hasAuthorship W2021002240A5066954535 @default.
• W2021002240 hasAuthorship W2021002240A5077615625 @default.
• W2021002240 hasConcept C11960822 @default.
• W2021002240 hasConcept C178790620 @default.
• W2021002240 hasConcept C185592680 @default.
• W2021002240 hasConcept C2775838275 @default.
• W2021002240 hasConcept C2776231299 @default.
• W2021002240 hasConcept C2776989580 @default.
• W2021002240 hasConcept C2777468819 @default.
• W2021002240 hasConcept C2777622882 @default.
• W2021002240 hasConcept C2778004101 @default.
• W2021002240 hasConcept C2778326061 @default.
• W2021002240 hasConcept C2778760513 @default.
• W2021002240 hasConcept C2779129087 @default.
• W2021002240 hasConcept C2779138974 @default.
• W2021002240 hasConcept C2781401929 @default.
• W2021002240 hasConcept C515207424 @default.
• W2021002240 hasConcept C519581460 @default.
• W2021002240 hasConcept C55493867 @default.
• W2021002240 hasConcept C79879829 @default.
• W2021002240 hasConcept C86803240 @default.
• W2021002240 hasConcept C95444343 @default.
• W2021002240 hasConceptScore W2021002240C11960822 @default.
• W2021002240 hasConceptScore W2021002240C178790620 @default.
• W2021002240 hasConceptScore W2021002240C185592680 @default.
• W2021002240 hasConceptScore W2021002240C2775838275 @default.
• W2021002240 hasConceptScore W2021002240C2776231299 @default.
• W2021002240 hasConceptScore W2021002240C2776989580 @default.
• W2021002240 hasConceptScore W2021002240C2777468819 @default.
• W2021002240 hasConceptScore W2021002240C2777622882 @default.

• next