FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021003061> ?p ?o ?g. }

• W2021003061 endingPage "373" @default.
• W2021003061 startingPage "364" @default.
• W2021003061 abstract "The alpha2A and alpha2C adrenergic receptor (AR) subtypes mediate antinociception when activated by the endogenous ligand norepinephrine. These receptors also produce antinociceptive synergy when activated concurrently with opioid receptor activation. The involvement of the opioid receptors in the mechanisms governing transcutaneous electrical nerve stimulation (TENS) has been well described. While spinal alpha-2 ARs do not appear to be involved in TENS antihyperalgesia in rats, the noradrenergic analgesic system also involves supraspinal and peripheral sites. Thus, a broader evaluation of the potential contribution of alpha-2 AR to TENS is warranted. The current study compared the antihyperalgesic efficacy of high (100 Hz) and low (4 Hz) frequency TENS in mutant mice lacking a functional alpha2A AR against their respective wildtype counterparts. The degree of secondary heat hyperalgesia induced by intra-articular injection of carrageenan/kaolin (3%) mixture did not differ among the experimental groups. However, the antihyperalgesia induced by both low and high frequency TENS was significantly diminished in alpha2A mutant mice compared to controls. The alpha2 adrenergic receptor selective antagonist, SK&F 86466, reversed TENS-mediated antihyperalgesia when delivered intra-articularly, but not when delivered intrathecally or intracerebroventricularly. These data suggest that peripheral alpha2 ARs contribute, in part, to TENS antihyperalgesia. This pharmacodynamic response is consistent with previous anatomical observations that alpha2A ARs are expressed on primary afferent neurons and macrophages near injured tissue." @default.
• W2021003061 created "2016-06-24" @default.
• W2021003061 creator A5001467888 @default.
• W2021003061 creator A5032361246 @default.
• W2021003061 creator A5054892722 @default.
• W2021003061 creator A5062314731 @default.
• W2021003061 creator A5065448782 @default.
• W2021003061 creator A5079914120 @default.
• W2021003061 date "2005-06-01" @default.
• W2021003061 modified "2023-10-01" @default.
• W2021003061 title "Transcutaneous electrical nerve stimulation activates peripherally located alpha-2A adrenergic receptors" @default.
• W2021003061 cites W1751408275 @default.
• W2021003061 cites W1799894364 @default.
• W2021003061 cites W1841227142 @default.
• W2021003061 cites W1963831720 @default.
• W2021003061 cites W1965336231 @default.
• W2021003061 cites W1974606274 @default.
• W2021003061 cites W1974865740 @default.
• W2021003061 cites W1975483594 @default.
• W2021003061 cites W1982324672 @default.
• W2021003061 cites W1983165959 @default.
• W2021003061 cites W1987753309 @default.
• W2021003061 cites W1988468898 @default.
• W2021003061 cites W1988899007 @default.
• W2021003061 cites W1989990644 @default.
• W2021003061 cites W1991383116 @default.
• W2021003061 cites W1999776567 @default.
• W2021003061 cites W2000493820 @default.
• W2021003061 cites W2000500546 @default.
• W2021003061 cites W2003996864 @default.
• W2021003061 cites W2005135333 @default.
• W2021003061 cites W2008735330 @default.
• W2021003061 cites W2009979296 @default.
• W2021003061 cites W2013314380 @default.
• W2021003061 cites W2013733676 @default.
• W2021003061 cites W2014007136 @default.
• W2021003061 cites W2014101780 @default.
• W2021003061 cites W2014909810 @default.
• W2021003061 cites W2016315625 @default.
• W2021003061 cites W2025604552 @default.
• W2021003061 cites W2028559363 @default.
• W2021003061 cites W2033667415 @default.
• W2021003061 cites W2034102455 @default.
• W2021003061 cites W2037205979 @default.
• W2021003061 cites W2047923111 @default.
• W2021003061 cites W2054436296 @default.
• W2021003061 cites W2055704007 @default.
• W2021003061 cites W2066310602 @default.
• W2021003061 cites W2068443973 @default.
• W2021003061 cites W2074640697 @default.
• W2021003061 cites W2074829766 @default.
• W2021003061 cites W2078072341 @default.
• W2021003061 cites W2080202671 @default.
• W2021003061 cites W2080536752 @default.
• W2021003061 cites W2080670277 @default.
• W2021003061 cites W2083287234 @default.
• W2021003061 cites W2084235775 @default.
• W2021003061 cites W2085032861 @default.
• W2021003061 cites W2085618426 @default.
• W2021003061 cites W2101978834 @default.
• W2021003061 cites W2114055974 @default.
• W2021003061 cites W2114725885 @default.
• W2021003061 cites W2155950699 @default.
• W2021003061 cites W2157492538 @default.
• W2021003061 cites W4240143568 @default.
• W2021003061 cites W4327634976 @default.
• W2021003061 doi "https://doi.org/10.1016/j.pain.2005.03.027" @default.
• W2021003061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15911163" @default.
• W2021003061 hasPublicationYear "2005" @default.
• W2021003061 type Work @default.
• W2021003061 sameAs 2021003061 @default.
• W2021003061 citedByCount "81" @default.
• W2021003061 countsByYear W20210030612012 @default.
• W2021003061 countsByYear W20210030612013 @default.
• W2021003061 countsByYear W20210030612014 @default.
• W2021003061 countsByYear W20210030612015 @default.
• W2021003061 countsByYear W20210030612016 @default.
• W2021003061 countsByYear W20210030612017 @default.
• W2021003061 countsByYear W20210030612018 @default.
• W2021003061 countsByYear W20210030612019 @default.
• W2021003061 countsByYear W20210030612020 @default.
• W2021003061 countsByYear W20210030612021 @default.
• W2021003061 countsByYear W20210030612022 @default.
• W2021003061 countsByYear W20210030612023 @default.
• W2021003061 crossrefType "journal-article" @default.
• W2021003061 hasAuthorship W2021003061A5001467888 @default.
• W2021003061 hasAuthorship W2021003061A5032361246 @default.
• W2021003061 hasAuthorship W2021003061A5054892722 @default.
• W2021003061 hasAuthorship W2021003061A5062314731 @default.
• W2021003061 hasAuthorship W2021003061A5065448782 @default.
• W2021003061 hasAuthorship W2021003061A5079914120 @default.
• W2021003061 hasConcept C126322002 @default.
• W2021003061 hasConcept C134018914 @default.
• W2021003061 hasConcept C142724271 @default.
• W2021003061 hasConcept C15490471 @default.
• W2021003061 hasConcept C158453852 @default.
• W2021003061 hasConcept C169760540 @default.
• W2021003061 hasConcept C170493617 @default.

• next