Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021003103> ?p ?o ?g. }
- W2021003103 endingPage "e22172" @default.
- W2021003103 startingPage "e22172" @default.
- W2021003103 abstract "The invention of intracytoplasmic sperm injection (ICSI) has possibly been the most important development in reproductive medicine, one that has given hope to thousands of infertile couples worldwide. However, concerns remain regarding the safety of this method since it is a more invasive procedure than in vitro fertilization (IVF), since a spermatozoon is injected into the oocyte cytoplasm. Using mice derived from IVF technology as a control, we assessed the influence of invasive microinjection in the process of transferring sperm into oocyte cytoplasm in ICSI procedure on the development and physiologic function of resultant offspring. Our results demonstrated that mice produced from ICSI and IVF had no significant difference in phenotypic indices including body weight, forelimb physiology, and learning and memory ability. However, increased spermatocyte apoptosis was observed in the testis of adult ICSI mice, when compared with IVF mice. And, decreased testis weight and marked damage of spermatogenic epithelia were found in aged ICSI mice. Furthermore, proteomic analysis verified that most of the differentiated proteins in testes between adult ICSI and IVF mice were those involved in regulation of apoptosis pathways. Our results demonstrated that the microinjection manipulation used in the ICSI procedure might pose potential risks to the fertility of male offspring. The changed expression of a series of proteins relating to apoptosis or proliferation might contribute to it. Further studies are necessary to better understand all the risks of ICSI." @default.
- W2021003103 created "2016-06-24" @default.
- W2021003103 creator A5008582313 @default.
- W2021003103 creator A5016315541 @default.
- W2021003103 creator A5032546338 @default.
- W2021003103 creator A5035272520 @default.
- W2021003103 creator A5039779354 @default.
- W2021003103 creator A5042850906 @default.
- W2021003103 creator A5049086579 @default.
- W2021003103 creator A5051580036 @default.
- W2021003103 creator A5058972118 @default.
- W2021003103 creator A5059500596 @default.
- W2021003103 creator A5061316406 @default.
- W2021003103 creator A5069645847 @default.
- W2021003103 date "2011-07-20" @default.
- W2021003103 modified "2023-10-15" @default.
- W2021003103 title "Microinjection Manipulation Resulted in the Increased Apoptosis of Spermatocytes in Testes from Intracytoplasmic Sperm Injection (ICSI) Derived Mice" @default.
- W2021003103 cites W1973858316 @default.
- W2021003103 cites W1974129037 @default.
- W2021003103 cites W1988655583 @default.
- W2021003103 cites W1992817906 @default.
- W2021003103 cites W1994580609 @default.
- W2021003103 cites W2000091990 @default.
- W2021003103 cites W2003225802 @default.
- W2021003103 cites W2005380259 @default.
- W2021003103 cites W2005893109 @default.
- W2021003103 cites W2006042243 @default.
- W2021003103 cites W2018221132 @default.
- W2021003103 cites W2022290943 @default.
- W2021003103 cites W2028690789 @default.
- W2021003103 cites W2034089747 @default.
- W2021003103 cites W2037735258 @default.
- W2021003103 cites W2039810057 @default.
- W2021003103 cites W2066312343 @default.
- W2021003103 cites W2066672702 @default.
- W2021003103 cites W2080100971 @default.
- W2021003103 cites W2087199631 @default.
- W2021003103 cites W2088821822 @default.
- W2021003103 cites W2104295025 @default.
- W2021003103 cites W2110167017 @default.
- W2021003103 cites W2110280725 @default.
- W2021003103 cites W2111651969 @default.
- W2021003103 cites W2125088534 @default.
- W2021003103 cites W2139396663 @default.
- W2021003103 cites W2140018835 @default.
- W2021003103 cites W2140322167 @default.
- W2021003103 cites W2143384972 @default.
- W2021003103 cites W2156555954 @default.
- W2021003103 cites W2159604992 @default.
- W2021003103 cites W2163411496 @default.
- W2021003103 cites W2166450089 @default.
- W2021003103 cites W2166830325 @default.
- W2021003103 cites W2169727912 @default.
- W2021003103 cites W2169812048 @default.
- W2021003103 cites W2315242749 @default.
- W2021003103 doi "https://doi.org/10.1371/journal.pone.0022172" @default.
- W2021003103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3140508" @default.
- W2021003103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21799787" @default.
- W2021003103 hasPublicationYear "2011" @default.
- W2021003103 type Work @default.
- W2021003103 sameAs 2021003103 @default.
- W2021003103 citedByCount "17" @default.
- W2021003103 countsByYear W20210031032012 @default.
- W2021003103 countsByYear W20210031032013 @default.
- W2021003103 countsByYear W20210031032014 @default.
- W2021003103 countsByYear W20210031032015 @default.
- W2021003103 countsByYear W20210031032017 @default.
- W2021003103 countsByYear W20210031032019 @default.
- W2021003103 countsByYear W20210031032020 @default.
- W2021003103 countsByYear W20210031032021 @default.
- W2021003103 countsByYear W20210031032022 @default.
- W2021003103 countsByYear W20210031032023 @default.
- W2021003103 crossrefType "journal-article" @default.
- W2021003103 hasAuthorship W2021003103A5008582313 @default.
- W2021003103 hasAuthorship W2021003103A5016315541 @default.
- W2021003103 hasAuthorship W2021003103A5032546338 @default.
- W2021003103 hasAuthorship W2021003103A5035272520 @default.
- W2021003103 hasAuthorship W2021003103A5039779354 @default.
- W2021003103 hasAuthorship W2021003103A5042850906 @default.
- W2021003103 hasAuthorship W2021003103A5049086579 @default.
- W2021003103 hasAuthorship W2021003103A5051580036 @default.
- W2021003103 hasAuthorship W2021003103A5058972118 @default.
- W2021003103 hasAuthorship W2021003103A5059500596 @default.
- W2021003103 hasAuthorship W2021003103A5061316406 @default.
- W2021003103 hasAuthorship W2021003103A5069645847 @default.
- W2021003103 hasBestOaLocation W20210031031 @default.
- W2021003103 hasConcept C104317684 @default.
- W2021003103 hasConcept C105702510 @default.
- W2021003103 hasConcept C148196450 @default.
- W2021003103 hasConcept C16685009 @default.
- W2021003103 hasConcept C179265757 @default.
- W2021003103 hasConcept C196843134 @default.
- W2021003103 hasConcept C2776053789 @default.
- W2021003103 hasConcept C2776632385 @default.
- W2021003103 hasConcept C2776690073 @default.
- W2021003103 hasConcept C2778278907 @default.
- W2021003103 hasConcept C2781087480 @default.
- W2021003103 hasConcept C512716672 @default.