Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021003345> ?p ?o ?g. }
- W2021003345 endingPage "299" @default.
- W2021003345 startingPage "299" @default.
- W2021003345 abstract "To determine the effects of tetrathiomolybdate (TM), a copper-chelating agent, on retinal angiogenesis and vascular endothelial growth factor (VEGF) in a mouse model of retinal neovascularization.Postnatal day (P)7 C57BL/6N mice were exposed to 75% +/- 2% oxygen for 5 days (P7-P11) and then returned to room air for 5 days (P12-P17) to induce retinal neovascularization. Beginning on P10 or P12, mice received daily intraperitoneal injections of TM or phosphate-buffered saline (PBS; control) through P17. Retinal neovascularization was examined by fluorescein dextran angiography after 5 days in room air and was quantitated histologically by counting the neovascular endothelial cell nuclei anterior to the inner limiting membrane. TM's effects on VEGF expression were measured by ELISA.TM-treated and control animals demonstrated comparable regions of retinal nonperfusion. Retinas from control mice at P17 contained neovascular tufts at the junction between perfused and nonperfused retina. The tufts contained numerous neovascular nuclei. Retinas from mice treated with TM beginning on P10 (2 days before returning to room air), but not P12, demonstrated a 41% reduction in neovascular cell nuclei compared with control mice (P <0.01). The P10-treated mice also demonstrated a 24% reduction of VEGF compared with control animals (P=0.01).TM significantly inhibits retinal neovascularization and VEGF production in a mouse model of retinal neovascularization." @default.
- W2021003345 created "2016-06-24" @default.
- W2021003345 creator A5009715853 @default.
- W2021003345 creator A5045488672 @default.
- W2021003345 creator A5049118958 @default.
- W2021003345 creator A5049627780 @default.
- W2021003345 creator A5082567021 @default.
- W2021003345 date "2005-01-01" @default.
- W2021003345 modified "2023-10-05" @default.
- W2021003345 title "Effects of Tetrathiomolybdate in a Mouse Model of Retinal Neovascularization" @default.
- W2021003345 cites W121642688 @default.
- W2021003345 cites W123664864 @default.
- W2021003345 cites W144276703 @default.
- W2021003345 cites W1497101473 @default.
- W2021003345 cites W1518373859 @default.
- W2021003345 cites W1528843291 @default.
- W2021003345 cites W1536521957 @default.
- W2021003345 cites W172186787 @default.
- W2021003345 cites W183134926 @default.
- W2021003345 cites W1966611885 @default.
- W2021003345 cites W1967004211 @default.
- W2021003345 cites W1969194948 @default.
- W2021003345 cites W1992134233 @default.
- W2021003345 cites W1992394132 @default.
- W2021003345 cites W1996990042 @default.
- W2021003345 cites W1999961827 @default.
- W2021003345 cites W2007917457 @default.
- W2021003345 cites W2027981213 @default.
- W2021003345 cites W2028108083 @default.
- W2021003345 cites W2042945618 @default.
- W2021003345 cites W2045616069 @default.
- W2021003345 cites W2055714163 @default.
- W2021003345 cites W2056311852 @default.
- W2021003345 cites W2058525931 @default.
- W2021003345 cites W2065203610 @default.
- W2021003345 cites W2069676076 @default.
- W2021003345 cites W2091035160 @default.
- W2021003345 cites W2106059645 @default.
- W2021003345 cites W2118775158 @default.
- W2021003345 cites W2125762952 @default.
- W2021003345 cites W2140520381 @default.
- W2021003345 cites W2147240090 @default.
- W2021003345 cites W2151599895 @default.
- W2021003345 cites W2152065691 @default.
- W2021003345 cites W2152349142 @default.
- W2021003345 cites W2163069245 @default.
- W2021003345 cites W2166797327 @default.
- W2021003345 cites W2169608059 @default.
- W2021003345 cites W2270149052 @default.
- W2021003345 cites W2612281319 @default.
- W2021003345 cites W2612675835 @default.
- W2021003345 cites W630700120 @default.
- W2021003345 cites W97251553 @default.
- W2021003345 cites W1601092960 @default.
- W2021003345 doi "https://doi.org/10.1167/iovs.04-0180" @default.
- W2021003345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15623788" @default.
- W2021003345 hasPublicationYear "2005" @default.
- W2021003345 type Work @default.
- W2021003345 sameAs 2021003345 @default.
- W2021003345 citedByCount "12" @default.
- W2021003345 countsByYear W20210033452012 @default.
- W2021003345 countsByYear W20210033452013 @default.
- W2021003345 crossrefType "journal-article" @default.
- W2021003345 hasAuthorship W2021003345A5009715853 @default.
- W2021003345 hasAuthorship W2021003345A5045488672 @default.
- W2021003345 hasAuthorship W2021003345A5049118958 @default.
- W2021003345 hasAuthorship W2021003345A5049627780 @default.
- W2021003345 hasAuthorship W2021003345A5082567021 @default.
- W2021003345 hasConcept C118487528 @default.
- W2021003345 hasConcept C134018914 @default.
- W2021003345 hasConcept C142724271 @default.
- W2021003345 hasConcept C167734588 @default.
- W2021003345 hasConcept C169760540 @default.
- W2021003345 hasConcept C185592680 @default.
- W2021003345 hasConcept C2777025900 @default.
- W2021003345 hasConcept C2777093970 @default.
- W2021003345 hasConcept C2778271429 @default.
- W2021003345 hasConcept C2778561011 @default.
- W2021003345 hasConcept C2779113765 @default.
- W2021003345 hasConcept C2780159080 @default.
- W2021003345 hasConcept C2780248432 @default.
- W2021003345 hasConcept C2780394083 @default.
- W2021003345 hasConcept C2780827179 @default.
- W2021003345 hasConcept C502942594 @default.
- W2021003345 hasConcept C71924100 @default.
- W2021003345 hasConcept C86803240 @default.
- W2021003345 hasConceptScore W2021003345C118487528 @default.
- W2021003345 hasConceptScore W2021003345C134018914 @default.
- W2021003345 hasConceptScore W2021003345C142724271 @default.
- W2021003345 hasConceptScore W2021003345C167734588 @default.
- W2021003345 hasConceptScore W2021003345C169760540 @default.
- W2021003345 hasConceptScore W2021003345C185592680 @default.
- W2021003345 hasConceptScore W2021003345C2777025900 @default.
- W2021003345 hasConceptScore W2021003345C2777093970 @default.
- W2021003345 hasConceptScore W2021003345C2778271429 @default.
- W2021003345 hasConceptScore W2021003345C2778561011 @default.
- W2021003345 hasConceptScore W2021003345C2779113765 @default.
- W2021003345 hasConceptScore W2021003345C2780159080 @default.