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- W2021004292 endingPage "975" @default.
- W2021004292 startingPage "965" @default.
- W2021004292 abstract "The complement system consists of about 35–40 proteins and glycoproteins present in blood plasma or on cell surfaces. Its main biological function is to recognise “foreign” particles and macromolecules, and to promote their elimination either by opsonisation or lysis. Although historically complement has been studied as a system for immune defence against bacteria, it has an important homeostatic role in which it recognises damaged or altered “self” components. Thus complement has major roles in both immune defence against microorganisms, and in clearance of damaged or “used” host components. Since complement proteins opsonise or lyse cells, complement can damage healthy host cells and tissues. The system is regulated by many endogenous regulatory proteins. Regulation is sometimes imperfect and both too much and too little complement activation is associated with many diseases. Excessive or inappropriate activation can cause tissue damage in diseases such as rheumatoid arthritis, age-related macular degeneration (AMD), multiple sclerosis, ischemia–reperfusion injury (e.g. ischemic stroke). Insufficient complement activity is associated with susceptibility to infection (mainly bacterial) and development of autoimmune disease, like SLE (systemic lupus erythematosus)." @default.
- W2021004292 created "2016-06-24" @default.
- W2021004292 creator A5015992232 @default.
- W2021004292 creator A5045570551 @default.
- W2021004292 date "2011-09-01" @default.
- W2021004292 modified "2023-09-29" @default.
- W2021004292 title "Complement in health and disease" @default.
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