Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021004319> ?p ?o ?g. }
- W2021004319 endingPage "1159" @default.
- W2021004319 startingPage "1147" @default.
- W2021004319 abstract "The clostridia cause many human and animal diseases, resulting in significant morbidity and mortality. Host damage results from the action of potent exotoxins, an important group of which is the large clostridial toxins (LCTs) produced by Clostridium difficile, Clostridium sordellii, Clostridium perfringens and Clostridium novyi. Knowledge of the structure and function of these toxins has been attained, however, apart from C. difficile, the regulatory pathways that control LCT production remain largely unknown. Here we show that LCT production in C. sordellii and C. perfringens is temporally regulated and repressed by glucose in a similar manner to C. difficile. Furthermore, we show that the TpeL-encoding gene of C. perfringens is located in an uncharacterized Pathogenicity Locus (PaLoc), along with accessory genes predicted to encode a bacteriophage holin-type protein and a TcdR-family alternative sigma factor, TpeR. Inactivation of tpeR demonstrated that TpeR is critical for C. perfringens TpeL production, in a similar manner to C. difficile TcdR and C. sordellii TcsR, but cross-complementation showed that TpeR is not functionally interchangeable with TcdR or TcsR. Although conserved mechanisms are employed by the clostridia to control LCT production there are important functional differences that distinguish members of the TcdR-family of clostridial alternative sigma factors." @default.
- W2021004319 created "2016-06-24" @default.
- W2021004319 creator A5030215396 @default.
- W2021004319 creator A5044564056 @default.
- W2021004319 creator A5053800143 @default.
- W2021004319 creator A5053957570 @default.
- W2021004319 creator A5064702944 @default.
- W2021004319 creator A5077097104 @default.
- W2021004319 creator A5081312384 @default.
- W2021004319 date "2014-11-01" @default.
- W2021004319 modified "2023-10-18" @default.
- W2021004319 title "Expression of the large clostridial toxins is controlled by conserved regulatory mechanisms" @default.
- W2021004319 cites W1506959512 @default.
- W2021004319 cites W1911807020 @default.
- W2021004319 cites W1916250014 @default.
- W2021004319 cites W1917165997 @default.
- W2021004319 cites W1917245719 @default.
- W2021004319 cites W1985522791 @default.
- W2021004319 cites W1985543936 @default.
- W2021004319 cites W1990499331 @default.
- W2021004319 cites W1992715230 @default.
- W2021004319 cites W1994041886 @default.
- W2021004319 cites W2000755885 @default.
- W2021004319 cites W2001999329 @default.
- W2021004319 cites W2005377507 @default.
- W2021004319 cites W2013726180 @default.
- W2021004319 cites W2015737379 @default.
- W2021004319 cites W2019639929 @default.
- W2021004319 cites W2025024815 @default.
- W2021004319 cites W2027830088 @default.
- W2021004319 cites W2030331971 @default.
- W2021004319 cites W2036913855 @default.
- W2021004319 cites W2046894146 @default.
- W2021004319 cites W2050499271 @default.
- W2021004319 cites W2055985922 @default.
- W2021004319 cites W2061298696 @default.
- W2021004319 cites W2076701025 @default.
- W2021004319 cites W2080963155 @default.
- W2021004319 cites W2082497696 @default.
- W2021004319 cites W2084323767 @default.
- W2021004319 cites W2085290399 @default.
- W2021004319 cites W2090134554 @default.
- W2021004319 cites W2092332746 @default.
- W2021004319 cites W2096891200 @default.
- W2021004319 cites W2100370202 @default.
- W2021004319 cites W2100837269 @default.
- W2021004319 cites W2102320488 @default.
- W2021004319 cites W2104902813 @default.
- W2021004319 cites W2105013839 @default.
- W2021004319 cites W2110146873 @default.
- W2021004319 cites W2113721855 @default.
- W2021004319 cites W2113998048 @default.
- W2021004319 cites W2116205144 @default.
- W2021004319 cites W2119850468 @default.
- W2021004319 cites W2127067932 @default.
- W2021004319 cites W2129366833 @default.
- W2021004319 cites W2135371566 @default.
- W2021004319 cites W2136855427 @default.
- W2021004319 cites W2137446111 @default.
- W2021004319 cites W2138650449 @default.
- W2021004319 cites W2139520476 @default.
- W2021004319 cites W2142902947 @default.
- W2021004319 cites W2153846214 @default.
- W2021004319 cites W2155399393 @default.
- W2021004319 cites W2159823628 @default.
- W2021004319 cites W2161364286 @default.
- W2021004319 cites W2163193604 @default.
- W2021004319 cites W2164012510 @default.
- W2021004319 cites W305537886 @default.
- W2021004319 doi "https://doi.org/10.1016/j.ijmm.2014.08.008" @default.
- W2021004319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25190355" @default.
- W2021004319 hasPublicationYear "2014" @default.
- W2021004319 type Work @default.
- W2021004319 sameAs 2021004319 @default.
- W2021004319 citedByCount "29" @default.
- W2021004319 countsByYear W20210043192015 @default.
- W2021004319 countsByYear W20210043192016 @default.
- W2021004319 countsByYear W20210043192017 @default.
- W2021004319 countsByYear W20210043192018 @default.
- W2021004319 countsByYear W20210043192019 @default.
- W2021004319 countsByYear W20210043192020 @default.
- W2021004319 countsByYear W20210043192021 @default.
- W2021004319 countsByYear W20210043192022 @default.
- W2021004319 countsByYear W20210043192023 @default.
- W2021004319 crossrefType "journal-article" @default.
- W2021004319 hasAuthorship W2021004319A5030215396 @default.
- W2021004319 hasAuthorship W2021004319A5044564056 @default.
- W2021004319 hasAuthorship W2021004319A5053800143 @default.
- W2021004319 hasAuthorship W2021004319A5053957570 @default.
- W2021004319 hasAuthorship W2021004319A5064702944 @default.
- W2021004319 hasAuthorship W2021004319A5077097104 @default.
- W2021004319 hasAuthorship W2021004319A5081312384 @default.
- W2021004319 hasConcept C104317684 @default.
- W2021004319 hasConcept C143065580 @default.
- W2021004319 hasConcept C188082640 @default.
- W2021004319 hasConcept C2776607351 @default.
- W2021004319 hasConcept C2777367657 @default.
- W2021004319 hasConcept C2778312467 @default.