FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021004501> ?p ?o ?g. }

• W2021004501 endingPage "539" @default.
• W2021004501 startingPage "534" @default.
• W2021004501 abstract "Chronic inflammatory processes might be involved in the progression and destabilization of atherosclerotic plaques. Therefore, identification of the mechanism underlying arterial inflammatory function might lead to the development of novel therapeutic strategies. Angiotensin II (AngII) is implicated in atherogenesis by activating the vascular inflammation system, mainly through monocyte chemotaxis. Therefore, we hypothesized that AngII increases plaque size and promotes destabilization of established atheromas by activating the monocyte chemoattractant protein-1 (MCP-1) pathway.We report here that 4-week infusion of AngII not only increased plaque size but also induced a destabilization phenotype (ie, increased macrophages and lipids and decreased collagen and smooth muscle cells) of pre-existing atherosclerotic lesions of hypercholesterolemic mice. AngII also enhanced the gene expression of inflammatory cytokines (TNFalpha, IL-6, etc.) and chemokines (MCP-1, CCR2, etc). Blockade of MCP-1, by transfecting the deletion mutant of the human MCP-1 gene into the skeletal muscles, limited AngII-induced progression and destabilization of established atherosclerotic lesions and suppressed the induction of proinflammatory genes.These data suggest that MCP-1 functions as a central inflammatory mediator in the AngII-induced progression and changes in plaque composition of established atheroma." @default.
• W2021004501 created "2016-06-24" @default.
• W2021004501 creator A5003472939 @default.
• W2021004501 creator A5004889289 @default.
• W2021004501 creator A5016567044 @default.
• W2021004501 creator A5017693285 @default.
• W2021004501 creator A5052919354 @default.
• W2021004501 creator A5053300236 @default.
• W2021004501 creator A5065901351 @default.
• W2021004501 creator A5075158215 @default.
• W2021004501 creator A5077522744 @default.
• W2021004501 creator A5083185852 @default.
• W2021004501 date "2004-03-01" @default.
• W2021004501 modified "2023-10-18" @default.
• W2021004501 title "Monocyte Chemoattractant Protein-1 Is an Essential Inflammatory Mediator in Angiotensin II-Induced Progression of Established Atherosclerosis in Hypercholesterolemic Mice" @default.
• W2021004501 cites W1516434930 @default.
• W2021004501 cites W1602000691 @default.
• W2021004501 cites W180946569 @default.
• W2021004501 cites W1976555160 @default.
• W2021004501 cites W1978040433 @default.
• W2021004501 cites W1985442806 @default.
• W2021004501 cites W2009452775 @default.
• W2021004501 cites W2017658686 @default.
• W2021004501 cites W2020780927 @default.
• W2021004501 cites W2037817605 @default.
• W2021004501 cites W2055502077 @default.
• W2021004501 cites W2056245899 @default.
• W2021004501 cites W2080373577 @default.
• W2021004501 cites W2081859430 @default.
• W2021004501 cites W2115163080 @default.
• W2021004501 cites W2127963975 @default.
• W2021004501 cites W2128044195 @default.
• W2021004501 cites W2133217116 @default.
• W2021004501 cites W2141299792 @default.
• W2021004501 cites W4313341332 @default.
• W2021004501 doi "https://doi.org/10.1161/01.atv.0000118275.60121.2b" @default.
• W2021004501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14739122" @default.
• W2021004501 hasPublicationYear "2004" @default.
• W2021004501 type Work @default.
• W2021004501 sameAs 2021004501 @default.
• W2021004501 citedByCount "99" @default.
• W2021004501 countsByYear W20210045012012 @default.
• W2021004501 countsByYear W20210045012013 @default.
• W2021004501 countsByYear W20210045012014 @default.
• W2021004501 countsByYear W20210045012015 @default.
• W2021004501 countsByYear W20210045012016 @default.
• W2021004501 countsByYear W20210045012017 @default.
• W2021004501 countsByYear W20210045012018 @default.
• W2021004501 countsByYear W20210045012019 @default.
• W2021004501 countsByYear W20210045012020 @default.
• W2021004501 countsByYear W20210045012021 @default.
• W2021004501 countsByYear W20210045012022 @default.
• W2021004501 countsByYear W20210045012023 @default.
• W2021004501 crossrefType "journal-article" @default.
• W2021004501 hasAuthorship W2021004501A5003472939 @default.
• W2021004501 hasAuthorship W2021004501A5004889289 @default.
• W2021004501 hasAuthorship W2021004501A5016567044 @default.
• W2021004501 hasAuthorship W2021004501A5017693285 @default.
• W2021004501 hasAuthorship W2021004501A5052919354 @default.
• W2021004501 hasAuthorship W2021004501A5053300236 @default.
• W2021004501 hasAuthorship W2021004501A5065901351 @default.
• W2021004501 hasAuthorship W2021004501A5075158215 @default.
• W2021004501 hasAuthorship W2021004501A5077522744 @default.
• W2021004501 hasAuthorship W2021004501A5083185852 @default.
• W2021004501 hasBestOaLocation W20210045011 @default.
• W2021004501 hasConcept C101666144 @default.
• W2021004501 hasConcept C126322002 @default.
• W2021004501 hasConcept C12823836 @default.
• W2021004501 hasConcept C13373296 @default.
• W2021004501 hasConcept C134018914 @default.
• W2021004501 hasConcept C164027704 @default.
• W2021004501 hasConcept C170493617 @default.
• W2021004501 hasConcept C185592680 @default.
• W2021004501 hasConcept C203014093 @default.
• W2021004501 hasConcept C206615009 @default.
• W2021004501 hasConcept C2107291 @default.
• W2021004501 hasConcept C2776914184 @default.
• W2021004501 hasConcept C2779318932 @default.
• W2021004501 hasConcept C2779395532 @default.
• W2021004501 hasConcept C2781184567 @default.
• W2021004501 hasConcept C2908929049 @default.
• W2021004501 hasConcept C2992686903 @default.
• W2021004501 hasConcept C54166955 @default.
• W2021004501 hasConcept C71924100 @default.
• W2021004501 hasConcept C86803240 @default.
• W2021004501 hasConceptScore W2021004501C101666144 @default.
• W2021004501 hasConceptScore W2021004501C126322002 @default.
• W2021004501 hasConceptScore W2021004501C12823836 @default.
• W2021004501 hasConceptScore W2021004501C13373296 @default.
• W2021004501 hasConceptScore W2021004501C134018914 @default.
• W2021004501 hasConceptScore W2021004501C164027704 @default.
• W2021004501 hasConceptScore W2021004501C170493617 @default.
• W2021004501 hasConceptScore W2021004501C185592680 @default.
• W2021004501 hasConceptScore W2021004501C203014093 @default.
• W2021004501 hasConceptScore W2021004501C206615009 @default.
• W2021004501 hasConceptScore W2021004501C2107291 @default.
• W2021004501 hasConceptScore W2021004501C2776914184 @default.
• W2021004501 hasConceptScore W2021004501C2779318932 @default.

• next