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• W2021004903 startingPage "956" @default.
• W2021004903 abstract "The BH3-only protein, PUMA, plays an important role in p53-mediated apoptosis. The apoptotic effect of PUMA on the mitochondria was studied using a p53-negative, human leukemia K562 cell line. Overexpression of PUMA was accompanied by an increased Bax expression, Bax conformational change, and translocation to mitochondria. A PUMA-BH3 peptide can induce Bax conformational change, cytochrome c release, and reduction in the mitochondrial membrane potential (DeltaPsi(m)) in isolated K562 mitochondria and can be inhibited by Bcl-XL. The homo-dimer of Bax/Bax was also weakly shown after mitochondria were treated with PUMA-BH3 peptide but may not be lethal for PUMA-induced apoptosis in K562 cells. Our results suggest that PUMA-induced Bax conformational change and Bax translocation to mitochondria can be separate events and the conformational change in Bax is crucial for PUMA-induced mitochondrial dysfunction." @default.
• W2021004903 created "2016-06-24" @default.
• W2021004903 creator A5011059993 @default.
• W2021004903 creator A5018297744 @default.
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• W2021004903 date "2003-10-01" @default.
• W2021004903 modified "2023-10-03" @default.
• W2021004903 title "Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia" @default.
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• W2021004903 doi "https://doi.org/10.1016/j.bbrc.2003.09.109" @default.
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