FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021006323> ?p ?o ?g. }

• W2021006323 endingPage "770" @default.
• W2021006323 startingPage "753" @default.
• W2021006323 abstract "Background: A number of proteins make up the Cdc28 complex in Saccharomyces cerevisiae, and regulate CDK activity. The cell cycle regulator Nik1 (Hsl1) is a protein kinase that interacts with the Cdc28 complex. The growth inhibitor Gin4 is structurally similar to Nik1 and may play a redundant role in the regulation of the cell cycle. We investigated the functions of Gin4 with respect to those of Nik1. Results: GIN4 was not essential for growth, and cells deficient in the GIN4 gene displayed no obvious defects in cell cycle regulation. The Δgin4 Δnik1 strain was temperature sensitive and showed an abnormal cell shape and FACS profile at permissive temperatures. GFP‐fused Gin4 was localized at the bud‐neck from late G1 to the M phase. Overproduction of the C‐terminal portion of Gin4 was toxic for cell growth, and this domain was required for the bud‐neck localization of Gin4‐GFP. High copy expression of Gin4‐GFP disturbed the bud‐neck localization of Gin4 in the abnormally elongated cells. Cytokinesis was defective in the Δgin4 cdc28 double mutants. The GST‐Gin4 fusion protein physically associates with the Cdc28 complex. Conclusions: Gin4 is a bud‐neck protein. GIN4 and NIK1 have distinct but partially overlapping functions. The major function of GIN4 is to ensure proper mitotic progression and cytokinesis." @default.
• W2021006323 created "2016-06-24" @default.
• W2021006323 creator A5002727514 @default.
• W2021006323 creator A5034949085 @default.
• W2021006323 creator A5060578424 @default.
• W2021006323 creator A5081256427 @default.
• W2021006323 date "1997-12-01" @default.
• W2021006323 modified "2023-10-16" @default.
• W2021006323 title "Gin4 of <i>S. cerevisiae</i> is a bud neck protein that interacts with the Cdc28 complex" @default.
• W2021006323 cites W11746033 @default.
• W2021006323 cites W1537782690 @default.
• W2021006323 cites W1541767983 @default.
• W2021006323 cites W1547330783 @default.
• W2021006323 cites W1593448845 @default.
• W2021006323 cites W1805665598 @default.
• W2021006323 cites W1839021542 @default.
• W2021006323 cites W1889045778 @default.
• W2021006323 cites W1938207098 @default.
• W2021006323 cites W1946122609 @default.
• W2021006323 cites W1966112176 @default.
• W2021006323 cites W1966797426 @default.
• W2021006323 cites W1967390330 @default.
• W2021006323 cites W1970783685 @default.
• W2021006323 cites W1973122477 @default.
• W2021006323 cites W1973221130 @default.
• W2021006323 cites W1975849939 @default.
• W2021006323 cites W1979213543 @default.
• W2021006323 cites W1983042608 @default.
• W2021006323 cites W1983325379 @default.
• W2021006323 cites W1992848268 @default.
• W2021006323 cites W1994066190 @default.
• W2021006323 cites W2000236119 @default.
• W2021006323 cites W2001564505 @default.
• W2021006323 cites W2001609760 @default.
• W2021006323 cites W2007187740 @default.
• W2021006323 cites W2009837683 @default.
• W2021006323 cites W2012015317 @default.
• W2021006323 cites W2018537155 @default.
• W2021006323 cites W2020679691 @default.
• W2021006323 cites W2020982275 @default.
• W2021006323 cites W2024519986 @default.
• W2021006323 cites W2027195059 @default.
• W2021006323 cites W2028801502 @default.
• W2021006323 cites W2032363524 @default.
• W2021006323 cites W2033172386 @default.
• W2021006323 cites W2033208702 @default.
• W2021006323 cites W2034603568 @default.
• W2021006323 cites W2034769470 @default.
• W2021006323 cites W2038340312 @default.
• W2021006323 cites W2046049550 @default.
• W2021006323 cites W2048875557 @default.
• W2021006323 cites W2051928958 @default.
• W2021006323 cites W2052034970 @default.
• W2021006323 cites W2053122851 @default.
• W2021006323 cites W2055475376 @default.
• W2021006323 cites W2056387850 @default.
• W2021006323 cites W2056652776 @default.
• W2021006323 cites W2059729638 @default.
• W2021006323 cites W2064153193 @default.
• W2021006323 cites W2071581153 @default.
• W2021006323 cites W2072720547 @default.
• W2021006323 cites W2085593164 @default.
• W2021006323 cites W2090848430 @default.
• W2021006323 cites W2091829207 @default.
• W2021006323 cites W2099661865 @default.
• W2021006323 cites W2100147739 @default.
• W2021006323 cites W2104509794 @default.
• W2021006323 cites W2107140925 @default.
• W2021006323 cites W2107424534 @default.
• W2021006323 cites W2109345949 @default.
• W2021006323 cites W2115685883 @default.
• W2021006323 cites W2116765394 @default.
• W2021006323 cites W2118056303 @default.
• W2021006323 cites W213154533 @default.
• W2021006323 cites W2137249911 @default.
• W2021006323 cites W2139632515 @default.
• W2021006323 cites W2140660011 @default.
• W2021006323 cites W2158004934 @default.
• W2021006323 cites W2161230893 @default.
• W2021006323 cites W2164469081 @default.
• W2021006323 cites W2175640000 @default.
• W2021006323 cites W2405902146 @default.
• W2021006323 cites W3022312892 @default.
• W2021006323 cites W589145703 @default.
• W2021006323 cites W93651929 @default.
• W2021006323 doi "https://doi.org/10.1046/j.1365-2443.1997.1590358.x" @default.
• W2021006323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9544703" @default.
• W2021006323 hasPublicationYear "1997" @default.
• W2021006323 type Work @default.
• W2021006323 sameAs 2021006323 @default.
• W2021006323 citedByCount "27" @default.
• W2021006323 countsByYear W20210063232012 @default.
• W2021006323 countsByYear W20210063232015 @default.
• W2021006323 countsByYear W20210063232016 @default.
• W2021006323 countsByYear W20210063232017 @default.
• W2021006323 countsByYear W20210063232018 @default.
• W2021006323 countsByYear W20210063232019 @default.
• W2021006323 countsByYear W20210063232020 @default.

• next