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• W2021006519 endingPage "R529" @default.
• W2021006519 startingPage "R518" @default.
• W2021006519 abstract "Thermoregulatory responses are partially controlled by the preoptic area and anterior hypothalamus (PO/AH), which contains a mixed population of temperature-sensitive and insensitive neurons. Immunohistochemical procedures identified the extent of various ionic channels in rat PO/AH neurons. These included pacemaker current channels [i.e., hyperpolarization-activated cyclic nucleotide-gated channels (HCN)], background potassium leak channels (TASK-1 and TRAAK), and transient receptor potential channel (TRP) TRPV4. PO/AH neurons showed dense TASK-1 and HCN-2 immunoreactivity and moderate TRAAK and HCN-4 immunoreactivity. In contrast, the neuronal cell bodies did not label for TRPV4, but instead, punctate labeling was observed in traversing axons or their terminal endings. On the basis of these results and previous electrophysiological studies, Hodgkin–Huxley-like models were constructed. These models suggest that most PO/AH neurons have the same types of ionic channels, but different levels of channel expression can explain the inherent properties of the various types of temperature-sensitive and insensitive neurons." @default.
• W2021006519 created "2016-06-24" @default.
• W2021006519 creator A5057350044 @default.
• W2021006519 creator A5063860296 @default.
• W2021006519 creator A5085027120 @default.
• W2021006519 creator A5089288259 @default.
• W2021006519 date "2006-09-01" @default.
• W2021006519 modified "2023-10-02" @default.
• W2021006519 title "Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity" @default.
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• W2021006519 doi "https://doi.org/10.1152/ajpregu.00039.2006" @default.
• W2021006519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16690776" @default.
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