Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021008575> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2021008575 endingPage "1534" @default.
- W2021008575 startingPage "1523" @default.
- W2021008575 abstract "Abstract A specific HPLC assay has been developed for determination of the radioprotective drug WR 2721. The method is based on precolumn derivatization of plasma with fluorescamine, separation with a C-18 cartridge and detection by fluorescence. An external standard was used for calibration, and values were adjusted based upon recovery of added 14C-labeled WR 2721. WR 2721 had a retention time of about 13 minutes using a mobile phase of acetonitrile/water (22:78), 0.01 M in dibutylammonium phosphate, at a flow rate of 2 mL/min. Sensitivity of the assay was characterized to 2 μg/mL, and detector response was linear over the range of 2 to 1100 μg/mL. The assay requires 90 μL of plasma and has a total chromatography time of about 45 minutes. 2-(3-Aminopropylamino)ethanethiol (WR 1065) and bis- [2- (3-aminopropylamino)ethyl]disulfide (WR 33278), metabolites of the drug, and a variety of primary amines were shown not to interfere with the assay. Suitability of this assay for pharmacokinetic studies was demons..." @default.
- W2021008575 created "2016-06-24" @default.
- W2021008575 creator A5014344674 @default.
- W2021008575 creator A5015737184 @default.
- W2021008575 creator A5019174869 @default.
- W2021008575 creator A5033676700 @default.
- W2021008575 creator A5062778836 @default.
- W2021008575 creator A5065907169 @default.
- W2021008575 date "1983-06-01" @default.
- W2021008575 modified "2023-10-14" @default.
- W2021008575 title "HPLC Assay forS-2-(3-Aminopropylamino)ethyl Phosphorothioate (WR 2721) in Plasma" @default.
- W2021008575 cites W1969804963 @default.
- W2021008575 cites W1983827226 @default.
- W2021008575 cites W1989743638 @default.
- W2021008575 cites W2014976223 @default.
- W2021008575 cites W4300154704 @default.
- W2021008575 doi "https://doi.org/10.1080/01483918308064869" @default.
- W2021008575 hasPublicationYear "1983" @default.
- W2021008575 type Work @default.
- W2021008575 sameAs 2021008575 @default.
- W2021008575 citedByCount "17" @default.
- W2021008575 crossrefType "journal-article" @default.
- W2021008575 hasAuthorship W2021008575A5014344674 @default.
- W2021008575 hasAuthorship W2021008575A5015737184 @default.
- W2021008575 hasAuthorship W2021008575A5019174869 @default.
- W2021008575 hasAuthorship W2021008575A5033676700 @default.
- W2021008575 hasAuthorship W2021008575A5062778836 @default.
- W2021008575 hasAuthorship W2021008575A5065907169 @default.
- W2021008575 hasConcept C185592680 @default.
- W2021008575 hasConcept C43617362 @default.
- W2021008575 hasConcept C556039675 @default.
- W2021008575 hasConcept C71924100 @default.
- W2021008575 hasConcept C98274493 @default.
- W2021008575 hasConceptScore W2021008575C185592680 @default.
- W2021008575 hasConceptScore W2021008575C43617362 @default.
- W2021008575 hasConceptScore W2021008575C556039675 @default.
- W2021008575 hasConceptScore W2021008575C71924100 @default.
- W2021008575 hasConceptScore W2021008575C98274493 @default.
- W2021008575 hasIssue "8" @default.
- W2021008575 hasLocation W20210085751 @default.
- W2021008575 hasOpenAccess W2021008575 @default.
- W2021008575 hasPrimaryLocation W20210085751 @default.
- W2021008575 hasRelatedWork W1531601525 @default.
- W2021008575 hasRelatedWork W1990781990 @default.
- W2021008575 hasRelatedWork W2246581804 @default.
- W2021008575 hasRelatedWork W2314643286 @default.
- W2021008575 hasRelatedWork W2606768298 @default.
- W2021008575 hasRelatedWork W2606769243 @default.
- W2021008575 hasRelatedWork W2748952813 @default.
- W2021008575 hasRelatedWork W2899084033 @default.
- W2021008575 hasRelatedWork W2948807893 @default.
- W2021008575 hasRelatedWork W2778153218 @default.
- W2021008575 hasVolume "6" @default.
- W2021008575 isParatext "false" @default.
- W2021008575 isRetracted "false" @default.
- W2021008575 magId "2021008575" @default.
- W2021008575 workType "article" @default.