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- W2021009478 abstract "Warfarin resistance can be defined as the inability to prolong the international normalized ratio (INR) into the therapeutic range when the anticoagulant is given at normally prescribed doses [1]. Warfarin inhibition by abusive green tea intake was ascribed to green tea high vitamin K content [2]. However, when infusions of green tea were analyzed, the concentration of vitamin K was lower than the detection limit [4]. At the Anticoagulation Clinic of Hospital dos Servidores do Estado, Rio de Janeiro, Brazil, three patients could overcomewarfarin resistancewhen caffeine intakewas restricted. It is important to notice that coffee and cola beverages also have low vitamin K content [3]. A 27-year-old female with previous history of four fetal losses and a stroke, had a diagnosis of antiphospholipid syndrome confirmed, and was placed on warfarin. Nonetheless, with 20 mg/day her INR repeatedly remained below 1.3. She was drinking more than 2 l of a Brazilian caffeine-rich soft drink guarana per day, six days a week. After guarana was withhold, her INR reached target range with 7.5 mg/day. She started to drink guarana again and her INR dropped to 1.2 after five days." @default.
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- W2021009478 date "2012-04-01" @default.
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- W2021009478 title "Warfarin resistance and caffeine containing beverages" @default.
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- W2021009478 doi "https://doi.org/10.1016/j.ijcard.2011.07.058" @default.
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