Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021010021> ?p ?o ?g. }
- W2021010021 endingPage "144" @default.
- W2021010021 startingPage "137" @default.
- W2021010021 abstract "Although lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMGCoA) reductase, has been shown to have anti-cancer actions, the effect on human hepatoma cells was not investigated. Moreover, the exact mechanism of this action is not fully understood. In this study we investigated the mechanism by which lovastatin induces apoptosis using HepG2 human hepatoblastoma cells. Lovastatin induced apoptotic cell death in a dose-dependent manner in the cells, assessed by the flow cytometric analysis. Treatment with mevalonic acid, a precursor of cholesterol, did not significantly suppress the lovastatin-induced apoptosis. Lovastatin induced a rapid and sustained increase in intracellular <TEX>$Ca^{2+}$</TEX> concentration. Treatment with EGTA, an extracellular <TEX>$Ca^{2+}$</TEX> chelator did not significantly alter the lovastatin-induced intracellular <TEX>$Ca^{2+}$</TEX> increase and apoptosis, whereas intracellular <TEX>$Ca^{2+}$</TEX> reduction with BAPTA/AM and intracellular <TEX>$Ca^{2+}$</TEX> release blockers (dantrolene and TMB-8) completely blocked these actions of lovastatin. In addition, the lovastatin-induced apoptosis was significantly reduced by a calpain inhibitor, a broad spectrum caspase inhibitor z-VAD-fmk and inhibitors specific for caspase-9 and caspase-3 (z-LEHD-fmk and z-DEVD-fmk, respectively), but not by an inhibitor specific for caspase-8 (z-IETD-fmk). Collectively, these results suggest that lovastatin induced apoptosis of HepG2 hepatoma cells through intracellular <TEX>$Ca^{2+}$</TEX> release and calpain activation, leading to triggering mitochondrial apoptotic pathway. These results further suggest that lovastatin may be valuable for the therapeutic management of human hepatoma." @default.
- W2021010021 created "2016-06-24" @default.
- W2021010021 creator A5063702772 @default.
- W2021010021 date "2007-09-30" @default.
- W2021010021 modified "2023-09-30" @default.
- W2021010021 title "Lovastatin Induces Apoptotic Cell Death by Activation of Intracellular Ca2+Signal in HepG2 Human Hepatoma Cells" @default.
- W2021010021 cites W1505355747 @default.
- W2021010021 cites W1528310990 @default.
- W2021010021 cites W1566777539 @default.
- W2021010021 cites W1644794975 @default.
- W2021010021 cites W1723790989 @default.
- W2021010021 cites W1745634660 @default.
- W2021010021 cites W1964617786 @default.
- W2021010021 cites W1966202238 @default.
- W2021010021 cites W1974028784 @default.
- W2021010021 cites W1980396417 @default.
- W2021010021 cites W1992019828 @default.
- W2021010021 cites W2000605323 @default.
- W2021010021 cites W2003966742 @default.
- W2021010021 cites W2012173926 @default.
- W2021010021 cites W2015538356 @default.
- W2021010021 cites W2045618968 @default.
- W2021010021 cites W2051210107 @default.
- W2021010021 cites W2059794282 @default.
- W2021010021 cites W2060184827 @default.
- W2021010021 cites W2060978652 @default.
- W2021010021 cites W2071124826 @default.
- W2021010021 cites W2071673129 @default.
- W2021010021 cites W2077265833 @default.
- W2021010021 cites W2085158671 @default.
- W2021010021 cites W2085921220 @default.
- W2021010021 cites W2095101852 @default.
- W2021010021 cites W2104807191 @default.
- W2021010021 cites W2112944951 @default.
- W2021010021 cites W2118068129 @default.
- W2021010021 cites W2126564019 @default.
- W2021010021 cites W2127205265 @default.
- W2021010021 cites W2135028284 @default.
- W2021010021 cites W2136929309 @default.
- W2021010021 cites W2146047031 @default.
- W2021010021 cites W2172205541 @default.
- W2021010021 cites W300178483 @default.
- W2021010021 cites W4242397592 @default.
- W2021010021 cites W50350130 @default.
- W2021010021 doi "https://doi.org/10.4062/biomolther.2007.15.3.137" @default.
- W2021010021 hasPublicationYear "2007" @default.
- W2021010021 type Work @default.
- W2021010021 sameAs 2021010021 @default.
- W2021010021 citedByCount "0" @default.
- W2021010021 crossrefType "journal-article" @default.
- W2021010021 hasAuthorship W2021010021A5063702772 @default.
- W2021010021 hasBestOaLocation W20210100211 @default.
- W2021010021 hasConcept C181199279 @default.
- W2021010021 hasConcept C185592680 @default.
- W2021010021 hasConcept C190283241 @default.
- W2021010021 hasConcept C2778163477 @default.
- W2021010021 hasConcept C2780019300 @default.
- W2021010021 hasConcept C2780940807 @default.
- W2021010021 hasConcept C28406088 @default.
- W2021010021 hasConcept C31573885 @default.
- W2021010021 hasConcept C55493867 @default.
- W2021010021 hasConcept C56928146 @default.
- W2021010021 hasConcept C79879829 @default.
- W2021010021 hasConcept C86803240 @default.
- W2021010021 hasConcept C95444343 @default.
- W2021010021 hasConcept C98274493 @default.
- W2021010021 hasConcept C98424977 @default.
- W2021010021 hasConceptScore W2021010021C181199279 @default.
- W2021010021 hasConceptScore W2021010021C185592680 @default.
- W2021010021 hasConceptScore W2021010021C190283241 @default.
- W2021010021 hasConceptScore W2021010021C2778163477 @default.
- W2021010021 hasConceptScore W2021010021C2780019300 @default.
- W2021010021 hasConceptScore W2021010021C2780940807 @default.
- W2021010021 hasConceptScore W2021010021C28406088 @default.
- W2021010021 hasConceptScore W2021010021C31573885 @default.
- W2021010021 hasConceptScore W2021010021C55493867 @default.
- W2021010021 hasConceptScore W2021010021C56928146 @default.
- W2021010021 hasConceptScore W2021010021C79879829 @default.
- W2021010021 hasConceptScore W2021010021C86803240 @default.
- W2021010021 hasConceptScore W2021010021C95444343 @default.
- W2021010021 hasConceptScore W2021010021C98274493 @default.
- W2021010021 hasConceptScore W2021010021C98424977 @default.
- W2021010021 hasIssue "3" @default.
- W2021010021 hasLocation W20210100211 @default.
- W2021010021 hasOpenAccess W2021010021 @default.
- W2021010021 hasPrimaryLocation W20210100211 @default.
- W2021010021 hasRelatedWork W1969886439 @default.
- W2021010021 hasRelatedWork W19916217 @default.
- W2021010021 hasRelatedWork W2004906000 @default.
- W2021010021 hasRelatedWork W2018576622 @default.
- W2021010021 hasRelatedWork W2021010021 @default.
- W2021010021 hasRelatedWork W2037949400 @default.
- W2021010021 hasRelatedWork W2074148448 @default.
- W2021010021 hasRelatedWork W2145626047 @default.
- W2021010021 hasRelatedWork W2314024519 @default.
- W2021010021 hasRelatedWork W2594560619 @default.
- W2021010021 hasVolume "15" @default.
- W2021010021 isParatext "false" @default.