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- W2021011796 abstract "In this article we use the published heat capacity data of Dragan et al. [A.I. Dragan, et al., The energetics of specific binding of AT-hooks from HMGA1 to target DNA, J. Mol. Biol. 327 (2003) 393-411] on the association of proteins with DNA duplexes to construct enthalpy probability distributions for the protein/DNA complexes formed in these systems. We first analyze the multistep equilibrium that determines the species concentrations in this system to determine whether or not the DNA-peptide complex goes cleanly to DNA single-strands and peptide. Using the heat capacity data for this case we employ the maximum-entropy method to construct enthalpy probability distribution functions for the species involved in this equilibrium. We find that the distribution functions for this system clearly show bimodal behavior indicating a two-state transition from complex to non-complex form." @default.
- W2021011796 created "2016-06-24" @default.
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- W2021011796 date "2007-02-01" @default.
- W2021011796 modified "2023-10-14" @default.
- W2021011796 title "Enthalpy distribution functions for protein-DNA complexes: Example of the binding of AT-hooks to target DNA" @default.
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- W2021011796 doi "https://doi.org/10.1016/j.bpc.2006.10.012" @default.
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